BDBM8448 2-[(5Z)-4-oxo-2-sulfanylidene-5-(1,3-thiazol-2-ylmethylidene)-1,3-thiazolidin-3-yl]acetic acid::Rhodanine-thiazole analogue 13
SMILES: OC(=O)CN1C(=S)S\C(=C/c2nccs2)C1=O
InChI Key: InChIKey=NXNJQVJDNPNFES-HYXAFXHYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Anthrax Lethal Factor (LF) (Bacillus anthracis) | BDBM8448 (2-[(5Z)-4-oxo-2-sulfanylidene-5-(1,3-thiazol-2-ylm...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 7.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Institute for Medical Research | Assay Description Fluorescence peptide cleavage assay was performed in a 96-well plate. Each reaction contained MAPKKide, LF, and the small-molecule inhibitor. The C-t... | Proc Natl Acad Sci U S A 102: 9499-504 (2005) Article DOI: 10.1073/pnas.0502733102 BindingDB Entry DOI: 10.7270/Q2TM78BQ | |||||||||||
More data for this Ligand-Target Pair |