BDBM8460 5-{[5-(4-chlorophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione::P5i-11::Thiobarbituric acid-furan analogue 25
SMILES: Clc1ccc(cc1)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)o1
InChI Key: InChIKey=NNWLPFQBLCNFON-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM8460 (5-{[5-(4-chlorophenyl)furan-2-yl]methylidene}-2-su...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
Sichuan University | Assay Description All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the... | Chem Biol Drug Des 89: 585-598 (2017) Article DOI: 10.1111/cbdd.12881 BindingDB Entry DOI: 10.7270/Q21V5CTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Anthrax Lethal Factor (LF) (Bacillus anthracis) | BDBM8460 (5-{[5-(4-chlorophenyl)furan-2-yl]methylidene}-2-su...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Burnham Institute | Assay Description Fluorescence peptide cleavage assay was performed in a 96-well plate. Each reaction contained MAPKKide, LF, and the small-molecule inhibitor. The C-t... | J Med Chem 49: 27-30 (2006) Article DOI: 10.1021/jm050892j BindingDB Entry DOI: 10.7270/Q2PV6HKJ | |||||||||||
More data for this Ligand-Target Pair |