BDBM84650 TC-34

SMILES: CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1

InChI Key: InChIKey=INWQHHRLNZWEFG-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 84650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.15E+4	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM84650 (TC-34) Show SMILES CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1 Show InChI InChI=1S/C20H23N3O2/c1-13(2)21-18-15-12-14(9-10-20(3,4)24)7-8-16(15)22-19(23-18)17-6-5-11-25-17/h5-13,24H,1-4H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	7.5	4
Parc de Recerca Biomedica de Barcelona					Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur...				Chembiochem 10: 464-78 (2009) Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K
					More data for this Ligand-Target Pair