BDBM84805 1-azolyl-4-phenyl-2-butanone, 7
SMILES: O=C(CCc1ccccc1)Cn1cncn1
InChI Key: InChIKey=WVMHBWUDAPTOQF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heme Oxygenase 2 (HO-2) (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | Bioorg Med Chem 21: 5145-53 (2013) Article DOI: 10.1016/j.bmc.2013.06.040 BindingDB Entry DOI: 10.7270/Q2FF3TSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme Oxygenase 1 (HO-1) (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | Bioorg Med Chem 21: 5145-53 (2013) Article DOI: 10.1016/j.bmc.2013.06.040 BindingDB Entry DOI: 10.7270/Q2FF3TSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme Oxygenase 1 (HO-1) (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+6 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Queen's University | Assay Description Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal... | Chem Biol Drug Des 75: 68-90 (2010) Article DOI: 10.1111/j.1747-0285.2009.00909.x BindingDB Entry DOI: 10.7270/Q25B0101 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme oxygenase 2 (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Inhibition of HO-2 in Sprague-Dawley rat brain microsomes using NADPH as substrate preincubated for 10 mins followed by substrate addition and measur... | Eur J Med Chem 167: 439-453 (2019) Article DOI: 10.1016/j.ejmech.2019.02.027 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme Oxygenase 2 (HO-2) (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Inhibition of HO-2 in Sprague-Dawley albino rat brain microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins ... | Eur J Med Chem 148: 54-62 (2018) Article DOI: 10.1016/j.ejmech.2018.02.007 BindingDB Entry DOI: 10.7270/Q28P633V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme Oxygenase 1 (HO-1) (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins... | Eur J Med Chem 148: 54-62 (2018) Article DOI: 10.1016/j.ejmech.2018.02.007 BindingDB Entry DOI: 10.7270/Q28P633V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme oxygenase 1 (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Inhibition of HO-1 in Sprague-Dawley rat spleen microsomes using NADPH as substrate preincubated for 10 mins followed by substrate addition and measu... | Eur J Med Chem 167: 439-453 (2019) Article DOI: 10.1016/j.ejmech.2019.02.027 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme Oxygenase 2 (HO-2) (Rattus norvegicus (rat)) | BDBM84805 (1-azolyl-4-phenyl-2-butanone, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Queen's University | Assay Description Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal... | Chem Biol Drug Des 75: 68-90 (2010) Article DOI: 10.1111/j.1747-0285.2009.00909.x BindingDB Entry DOI: 10.7270/Q25B0101 | |||||||||||
More data for this Ligand-Target Pair |