BDBM84847 1-azolyl-4-phenyl-2-butanone, 49a::CHEMBL558183

SMILES: C(CC1(Cn2ccnc2)OCCO1)c1ccccc1

InChI Key: InChIKey=GKXREDWUTLNBPG-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 84847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Heme Oxygenase 1 (HO-1) (Rattus norvegicus (rat))	BDBM84847 (1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183) Show SMILES C(CC1(Cn2ccnc2)OCCO1)c1ccccc1 Show InChI InChI=1S/C15H18N2O2/c1-2-4-14(5-3-1)6-7-15(18-10-11-19-15)12-17-9-8-16-13-17/h1-5,8-9,13H,6-7,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	7.4	25
Queen's University					Assay Description Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal...				Chem Biol Drug Des 75: 68-90 (2010) Article DOI: 10.1111/j.1747-0285.2009.00909.x BindingDB Entry DOI: 10.7270/Q25B0101
					More data for this Ligand-Target Pair
Heme Oxygenase 2 (HO-2) (Rattus norvegicus (rat))	BDBM84847 (1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183) Show SMILES C(CC1(Cn2ccnc2)OCCO1)c1ccccc1 Show InChI InChI=1S/C15H18N2O2/c1-2-4-14(5-3-1)6-7-15(18-10-11-19-15)12-17-9-8-16-13-17/h1-5,8-9,13H,6-7,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.4	25
Queen's University					Assay Description Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal...				Chem Biol Drug Des 75: 68-90 (2010) Article DOI: 10.1111/j.1747-0285.2009.00909.x BindingDB Entry DOI: 10.7270/Q25B0101
					More data for this Ligand-Target Pair
Heme Oxygenase 1 (HO-1) (Rattus norvegicus (rat))	BDBM84847 (1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183) Show SMILES C(CC1(Cn2ccnc2)OCCO1)c1ccccc1 Show InChI InChI=1S/C15H18N2O2/c1-2-4-14(5-3-1)6-7-15(18-10-11-19-15)12-17-9-8-16-13-17/h1-5,8-9,13H,6-7,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
University of Catania Curated by ChEMBL					Assay Description Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins...				Eur J Med Chem 148: 54-62 (2018) Article DOI: 10.1016/j.ejmech.2018.02.007 BindingDB Entry DOI: 10.7270/Q28P633V
					More data for this Ligand-Target Pair
Heme Oxygenase 1 (HO-1) (Rattus norvegicus (rat))	BDBM84847 (1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183) Show SMILES C(CC1(Cn2ccnc2)OCCO1)c1ccccc1 Show InChI InChI=1S/C15H18N2O2/c1-2-4-14(5-3-1)6-7-15(18-10-11-19-15)12-17-9-8-16-13-17/h1-5,8-9,13H,6-7,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Queen's University Curated by ChEMBL					Assay Description Inhibition of Sprague-Dawley rat spleen microsome HO1				Bioorg Med Chem 15: 3225-34 (2007) Article DOI: 10.1016/j.bmc.2007.02.034 BindingDB Entry DOI: 10.7270/Q2MG7QBV
					More data for this Ligand-Target Pair
Heme Oxygenase 2 (HO-2) (Rattus norvegicus (rat))	BDBM84847 (1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183) Show SMILES C(CC1(Cn2ccnc2)OCCO1)c1ccccc1 Show InChI InChI=1S/C15H18N2O2/c1-2-4-14(5-3-1)6-7-15(18-10-11-19-15)12-17-9-8-16-13-17/h1-5,8-9,13H,6-7,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Catania Curated by ChEMBL					Assay Description Inhibition of HO-2 in Sprague-Dawley albino rat brain microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins ...				Eur J Med Chem 148: 54-62 (2018) Article DOI: 10.1016/j.ejmech.2018.02.007 BindingDB Entry DOI: 10.7270/Q28P633V
					More data for this Ligand-Target Pair
Heme Oxygenase 2 (HO-2) (Rattus norvegicus (rat))	BDBM84847 (1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183) Show SMILES C(CC1(Cn2ccnc2)OCCO1)c1ccccc1 Show InChI InChI=1S/C15H18N2O2/c1-2-4-14(5-3-1)6-7-15(18-10-11-19-15)12-17-9-8-16-13-17/h1-5,8-9,13H,6-7,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Queen's University Curated by ChEMBL					Assay Description Inhibition of Sprague-Dawley rat brain microsome HO2				Bioorg Med Chem 15: 3225-34 (2007) Article DOI: 10.1016/j.bmc.2007.02.034 BindingDB Entry DOI: 10.7270/Q2MG7QBV
					More data for this Ligand-Target Pair