BDBM85065 CAS_117946-91-5::Luzindole::NSC_122162

SMILES: CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12

InChI Key: InChIKey=WVVXBPKOIZGVNS-UHFFFAOYSA-N

Data: 19 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 85065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The German University in Cairo Curated by ChEMBL					Assay Description Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells				J Med Chem 57: 3161-85 (2014) Article DOI: 10.1021/jm401343c BindingDB Entry DOI: 10.7270/Q218381K
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	10.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	11.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit&agrove; degli Studi di Milano Curated by PDSP Ki Database									Br J Pharmacol 127: 1288-94 (1999) Article DOI: 10.1038/sj.bjp.0702658 BindingDB Entry DOI: 10.7270/Q20G3HQ6
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	14.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development, Ltd. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 1239-45 (1998) BindingDB Entry DOI: 10.7270/Q2PK0DPM
					More data for this Ligand-Target Pair
Melatonin (RABBIT)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	26.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998) Article DOI: 10.1007/pl00005288 BindingDB Entry DOI: 10.7270/Q2WW7G6S
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	44.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by ChEMBL					Assay Description Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assa...				J Med Chem 43: 1050-61 (2000) BindingDB Entry DOI: 10.7270/Q2VQ33DC
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	158	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The German University in Cairo Curated by ChEMBL					Assay Description Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells				J Med Chem 57: 3161-85 (2014) Article DOI: 10.1021/jm401343c BindingDB Entry DOI: 10.7270/Q218381K
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	158	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	251	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development, Ltd. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 1239-45 (1998) BindingDB Entry DOI: 10.7270/Q2PK0DPM
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	251	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development, Ltd. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 1239-45 (1998) BindingDB Entry DOI: 10.7270/Q2PK0DPM
					More data for this Ligand-Target Pair
Melatonin (RABBIT)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	435	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	513	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998) Article DOI: 10.1007/pl00005288 BindingDB Entry DOI: 10.7270/Q2WW7G6S
					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	603	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by ChEMBL					Assay Description Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assa...				J Med Chem 43: 1050-61 (2000) BindingDB Entry DOI: 10.7270/Q2VQ33DC
					More data for this Ligand-Target Pair
Melatonin (GUINEA PIG)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	676	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development, Ltd. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 1239-45 (1998) BindingDB Entry DOI: 10.7270/Q2PK0DPM
					More data for this Ligand-Target Pair
Melatonin (GUINEA PIG)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	933	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development, Ltd. Curated by PDSP Ki Database									J Pharmacol Exp Ther 285: 1239-45 (1998) BindingDB Entry DOI: 10.7270/Q2PK0DPM
					More data for this Ligand-Target Pair
Melatonin receptor type 1C (Gallus gallus)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Binding affinity towards melatonin receptor, determined in chicken brain membranes using [2-125I]melatonin				J Med Chem 41: 451-67 (1998) Article DOI: 10.1021/jm970246n BindingDB Entry DOI: 10.7270/Q2154KSH
					More data for this Ligand-Target Pair
Melatonin (Chick)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.74E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998) Article DOI: 10.1007/pl00005288 BindingDB Entry DOI: 10.7270/Q2WW7G6S
					More data for this Ligand-Target Pair
Melatonin 1C (Xenopus)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
King's College London Curated by PDSP Ki Database									Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998) Article DOI: 10.1007/pl00005288 BindingDB Entry DOI: 10.7270/Q2WW7G6S
					More data for this Ligand-Target Pair
Melatonin 1C (Xenopus)	BDBM85065 (CAS_117946-91-5 | Luzindole | NSC_122162) Show SMILES CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12 Show InChI InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Antagonist activity in Xenopus laevis melanophores assessed as melatoninergic activity after 60 mins				Eur J Med Chem 42: 1004-13 (2007) Article DOI: 10.1016/j.ejmech.2007.01.005 BindingDB Entry DOI: 10.7270/Q2B859BK
					More data for this Ligand-Target Pair