BindingDB PrimarySearch

BDBM85079 2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-yl]-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide::CHEMBL79261::DU-125530::DU125530

SMILES: Clc1cc2OCCOc2c(c1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1

InChI Key: InChIKey=LYXKFNHUJJDTIA-UHFFFAOYSA-N

Data: 10 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 85079
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
HTR1A (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.708	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Solvay Pharma Curated by ChEMBL					Assay Description Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranes				Bioorg Med Chem Lett 8: 2457-62 (1999) BindingDB Entry DOI: 10.7270/Q2KS6SQ1
Solvay Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
DRD2 (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
adrenergic Alpha1 (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
DRD3 (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR2A (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR2C (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	750	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR1B (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	890	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR3A (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HTR1D (pigeon)	BDBM85079 (2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CNS-Pharmacology Curated by PDSP K_i Database									Eur J Pharmacol 325: 145-53 (1997) Article DOI: 10.1016/s0014-2999(97)00131-3 BindingDB Entry DOI: 10.7270/Q2319TDM
CNS-Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair