null
SMILES: COc1cccc(c1)-c1n[nH]c2c(N=NCc3ccncc3)ncnc12
InChI Key: InChIKey=AAOVCUZTOYSLHK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM8540 (4-[(1E)-{2-[3-(3-methoxyphenyl)-1H-pyrazolo[4,3-d]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | 7.2 | 22 |
GlaxoSmithKline | Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-33P] ATP. Af... | Bioorg Med Chem Lett 16: 2091-4 (2006) Article DOI: 10.1016/j.bmcl.2006.01.057 BindingDB Entry DOI: 10.7270/Q25X274X | |||||||||||
More data for this Ligand-Target Pair |