BindingDB PrimarySearch

BDBM85822 Demethyl-AMPA::OFQ/N::OFQ/N (1-11)::OFQ/N (1-11),[Tyr10]

SMILES: [#6]-[#6@@H](-[#8])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O

InChI Key: InChIKey=RHMALYOXPBRJBG-CGUXNFSNSA-N

Data: 13 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 85822
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Section of Pharmacology Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 1114-23 (2005) Article DOI: 10.1124/jpet.104.077339 BindingDB Entry DOI: 10.7270/Q2222SC4
Section of Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (MOUSE)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Section of Pharmacology Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 1114-23 (2005) Article DOI: 10.1124/jpet.104.077339 BindingDB Entry DOI: 10.7270/Q2222SC4
Section of Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (MOUSE)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by PDSP K_i Database									Pharmacol Rev 53: 381-415 (2001) BindingDB Entry DOI: 10.7270/Q2QJ7FWB
McGill University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (MOUSE)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Section of Pharmacology Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 1114-23 (2005) Article DOI: 10.1124/jpet.104.077339 BindingDB Entry DOI: 10.7270/Q2222SC4
Section of Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (MOUSE)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	8.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by PDSP K_i Database									Pharmacol Rev 53: 381-415 (2001) BindingDB Entry DOI: 10.7270/Q2QJ7FWB
McGill University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (GUINEA PIG)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	11.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Section of Pharmacology Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 1114-23 (2005) Article DOI: 10.1124/jpet.104.077339 BindingDB Entry DOI: 10.7270/Q2222SC4
Section of Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (MOUSE)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	17.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Section of Pharmacology Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 1114-23 (2005) Article DOI: 10.1124/jpet.104.077339 BindingDB Entry DOI: 10.7270/Q2222SC4
Section of Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (RAT)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	57.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Section of Pharmacology Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 1114-23 (2005) Article DOI: 10.1124/jpet.104.077339 BindingDB Entry DOI: 10.7270/Q2222SC4
Section of Pharmacology Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (MOUSE)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	79.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by PDSP K_i Database									Pharmacol Rev 53: 381-415 (2001) BindingDB Entry DOI: 10.7270/Q2QJ7FWB
McGill University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Nociceptin/Orphanin FQ, NOP receptor (MOUSE)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	262	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by PDSP K_i Database									Pharmacol Rev 53: 381-415 (2001) BindingDB Entry DOI: 10.7270/Q2QJ7FWB
McGill University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by PDSP K_i Database									Chirality 13: 523-32 (2001) Article DOI: 10.1002/chir.1172 BindingDB Entry DOI: 10.7270/Q2Z31X6K
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by PDSP K_i Database									Chirality 13: 523-32 (2001) Article DOI: 10.1002/chir.1172 BindingDB Entry DOI: 10.7270/Q2Z31X6K
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM85822 (Demethyl-AMPA \| OFQ/N \| OFQ/N (1-11) \| OFQ/N (1-11...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by PDSP K_i Database									Chirality 13: 523-32 (2001) Article DOI: 10.1002/chir.1172 BindingDB Entry DOI: 10.7270/Q2Z31X6K
					More data for this Ligand-Target Pair