BDBM86170 Dimethylhistaprodifen::N,N-Dimethyl-2-(3,3-diphenylpropyl)-1H-imidazole-4-(ethanamine)

SMILES: CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1

InChI Key: InChIKey=GNBOIGBQIBQOIA-UHFFFAOYSA-N

Data: 2 KI  13 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 86170   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 1104-15 (2003) Article DOI: 10.1124/jpet.103.049619 BindingDB Entry DOI: 10.7270/Q2HM5708
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 1104-15 (2003) Article DOI: 10.1124/jpet.103.049619 BindingDB Entry DOI: 10.7270/Q2HM5708
					More data for this Ligand-Target Pair
HTR4 (RAT)	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>1.58E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 4 receptor of rat				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.38	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Antagonism of guinea pig ileum contraction at 100 nM mepyramine				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	7.76E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Homo sapiens (Human))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>1.58E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 3 receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	0.776	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Antagonism of guinea pig ileum contraction at 100 nM mepyramine				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
HRH3 (GUINEA PIG)	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>1.58E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Histamine H3 receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	3.72E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 2A receptor of rat				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	>3.16E+4	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards 5-hydroxytryptamine 1B receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Muscarinic acetylcholine receptor M3 of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (GUINEA PIG)	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.63E+4	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Beta-1 adrenergic receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM86170 (Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...) Show SMILES CN(C)CCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1 Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.63E+4	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was evaluated for its antagonist affinity towards Histamine H2 receptor of guinea pig				J Med Chem 43: 1071-84 (2000) BindingDB Entry DOI: 10.7270/Q2MC918D
					More data for this Ligand-Target Pair