BDBM86171 ARPROMIDINE::Arpromidine::CAS_65895::NSC_65895

SMILES: NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1

InChI Key: InChIKey=KZZIVOLMJPSDEP-UHFFFAOYSA-N

Data: 2 KI  2 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 86171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86171 (ARPROMIDINE | Arpromidine | CAS_65895 | NSC_65895) Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	33.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 1104-15 (2003) Article DOI: 10.1124/jpet.103.049619 BindingDB Entry DOI: 10.7270/Q2HM5708
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM86171 (ARPROMIDINE | Arpromidine | CAS_65895 | NSC_65895) Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	353	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 1104-15 (2003) Article DOI: 10.1124/jpet.103.049619 BindingDB Entry DOI: 10.7270/Q2HM5708
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86171 (ARPROMIDINE | Arpromidine | CAS_65895 | NSC_65895) Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	22.4	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced positive chronotropic activity				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM86171 (ARPROMIDINE | Arpromidine | CAS_65895 | NSC_65895) Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	9.77	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM86171 (ARPROMIDINE | Arpromidine | CAS_65895 | NSC_65895) Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	22.4	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.				J Med Chem 32: 1963-70 (1989) BindingDB Entry DOI: 10.7270/Q2BG2Q57
					More data for this Ligand-Target Pair