Found 13 hits for monomerid = 86248 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium channel (ATP modulatory)
(GUINEA PIG) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | Reactome pathway
UniProtKB/TrEMBL
GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
Mol Pharmacol 64: 143-53 (2003)
Article DOI: 10.1124/mol.64.1.143 BindingDB Entry DOI: 10.7270/Q22B8WMJ |
More data for this Ligand-Target Pair | |
Potassium channel (ATP modulatory)
(GUINEA PIG) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | Reactome pathway
UniProtKB/TrEMBL
GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by PDSP Ki Database
| |
Mol Pharmacol 64: 143-53 (2003)
Article DOI: 10.1124/mol.64.1.143 BindingDB Entry DOI: 10.7270/Q22B8WMJ |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.94E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a |
University of Perugia
Curated by ChEMBL
| Assay Description Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currents |
J Med Chem 50: 2117-26 (2007)
Article DOI: 10.1021/jm061440p BindingDB Entry DOI: 10.7270/Q2PK0FTT |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research & Development
Curated by ChEMBL
| Assay Description Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytes |
Bioorg Med Chem Lett 14: 813-6 (2004)
BindingDB Entry DOI: 10.7270/Q29P312R |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | 1.98E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ... |
J Med Chem 45: 4171-87 (2002)
BindingDB Entry DOI: 10.7270/Q2SF2VGM |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Beta-cell KATP channel |
Bioorg Med Chem Lett 12: 2977-80 (2002)
BindingDB Entry DOI: 10.7270/Q20V8C4M |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a |
University of Perugia
Curated by ChEMBL
| Assay Description Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarization |
J Med Chem 50: 2117-26 (2007)
Article DOI: 10.1021/jm061440p BindingDB Entry DOI: 10.7270/Q2PK0FTT |
More data for this Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 2.30E+5 | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Binding affinity to NAMPT (2 to 491) (unknown origin) by surface plasmon resonance analysis |
J Med Chem 57: 770-92 (2014)
Article DOI: 10.1021/jm4015108 BindingDB Entry DOI: 10.7270/Q2BC412B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 2.35E+4 | n/a | n/a | n/a | n/a |
Universite de Liege
Curated by ChEMBL
| Assay Description Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assay |
J Med Chem 53: 147-54 (2010)
Article DOI: 10.1021/jm9010093 BindingDB Entry DOI: 10.7270/Q2C82B7T |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 7.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 1
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | DIAZOXIDE | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Patents
| PubMed
| n/a | n/a | 7.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without... |
J Med Chem 45: 4171-87 (2002)
BindingDB Entry DOI: 10.7270/Q2SF2VGM |
More data for this Ligand-Target Pair | |