Found 6 hits for monomerid = 86283 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| PDB Article PubMed
| 2.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 307: 322-30 (2003)
Article DOI: 10.1124/jpet.103.053074 BindingDB Entry DOI: 10.7270/Q2542M50 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| PDB Article PubMed
| 32.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 307: 322-30 (2003)
Article DOI: 10.1124/jpet.103.053074 BindingDB Entry DOI: 10.7270/Q2542M50 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| Article PubMed
| 224 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 307: 138-45 (2003)
Article DOI: 10.1124/jpet.103.053975 BindingDB Entry DOI: 10.7270/Q28W3BVJ |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| Article PubMed
| 1.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 307: 138-45 (2003)
Article DOI: 10.1124/jpet.103.053975 BindingDB Entry DOI: 10.7270/Q28W3BVJ |
More data for this Ligand-Target Pair | |
GABA-B receptor 1/2
(Homo sapiens (Human)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 741 | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTP-gamma-S binding |
Bioorg Med Chem Lett 17: 6206-11 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.023 BindingDB Entry DOI: 10.7270/Q2N300RD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid type B receptor subunit 1
(Homo sapiens (Human)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| PDB Article PubMed
| n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
IntelliSyn Pharma
Curated by ChEMBL
| Assay Description Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibitio... |
Bioorg Med Chem Lett 27: 2239-2258 (2017)
Article DOI: 10.1016/j.bmcl.2017.03.084 BindingDB Entry DOI: 10.7270/Q2VT1VJJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |