BDBM86341 Phosphodiester analog, 4j::Phosphodiester analog, 4j (S4A)
SMILES: CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O
InChI Key: InChIKey=ZDQJNYLFGPXANH-XKSQAVIKSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM86341 (Phosphodiester analog, 4j | Phosphodiester analog,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
National Cancer Institute-Frederick | Assay Description The evaluation of Plk1 PBD binding affinities of the synthetic compounds using an ELISA-based 96-well assay. | Nat Chem Biol 7: 595-601 (2011) Article DOI: 10.1038/nchembio.614 BindingDB Entry DOI: 10.7270/Q2CN72GB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM86341 (Phosphodiester analog, 4j | Phosphodiester analog,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | 8.0 | 25 |
National Cancer Institute-Frederick | Assay Description The evaluation of Plk1 PBD binding affinities of the synthetic compounds using an ELISA-based 96-well assay. | Nat Chem Biol 7: 595-601 (2011) Article DOI: 10.1038/nchembio.614 BindingDB Entry DOI: 10.7270/Q2CN72GB | |||||||||||
More data for this Ligand-Target Pair |