BindingDB PrimarySearch

BDBM86632 JNK-IN-7

SMILES: CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1

InChI Key: InChIKey=RADRIIWGHYFWPP-WEVVVXLNSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 86632
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.54	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School					Assay Description The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.				Chem Biol 19: 140-54 (2012) Article DOI: 10.1016/j.chembiol.2011.11.010 BindingDB Entry DOI: 10.7270/Q2K35S8X
Harvard Medical School					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.99	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School					Assay Description The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.				Chem Biol 19: 140-54 (2012) Article DOI: 10.1016/j.chembiol.2011.11.010 BindingDB Entry DOI: 10.7270/Q2K35S8X
Harvard Medical School					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School					Assay Description The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.				Chem Biol 19: 140-54 (2012) Article DOI: 10.1016/j.chembiol.2011.11.010 BindingDB Entry DOI: 10.7270/Q2K35S8X
Harvard Medical School					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Inhibition of JNK2 (unknown origin) after 1 hr incubation				J Med Chem 58: 72-95 (2015) Article DOI: 10.1021/jm501212r BindingDB Entry DOI: 10.7270/Q2JH3NVZ
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Inhibition of JNK1 (unknown origin) after 1 hr incubation				J Med Chem 58: 72-95 (2015) Article DOI: 10.1021/jm501212r BindingDB Entry DOI: 10.7270/Q2JH3NVZ
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation				J Med Chem 58: 72-95 (2015) Article DOI: 10.1021/jm501212r BindingDB Entry DOI: 10.7270/Q2JH3NVZ
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation				J Med Chem 58: 72-95 (2015) Article DOI: 10.1021/jm501212r BindingDB Entry DOI: 10.7270/Q2JH3NVZ
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM86632 (JNK-IN-7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Inhibition of JNK3 (unknown origin) after 1 hr incubation				J Med Chem 58: 72-95 (2015) Article DOI: 10.1021/jm501212r BindingDB Entry DOI: 10.7270/Q2JH3NVZ
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair