null
SMILES: CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
InChI Key: InChIKey=XLLHFYYRDKVYSQ-IZZDOVSWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 8 (Homo sapiens (Human)) | BDBM86637 (JNK-IN-12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format. | Chem Biol 19: 140-54 (2012) Article DOI: 10.1016/j.chembiol.2011.11.010 BindingDB Entry DOI: 10.7270/Q2K35S8X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 10 (Homo sapiens (Human)) | BDBM86637 (JNK-IN-12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format. | Chem Biol 19: 140-54 (2012) Article DOI: 10.1016/j.chembiol.2011.11.010 BindingDB Entry DOI: 10.7270/Q2K35S8X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 9 (Homo sapiens (Human)) | BDBM86637 (JNK-IN-12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format. | Chem Biol 19: 140-54 (2012) Article DOI: 10.1016/j.chembiol.2011.11.010 BindingDB Entry DOI: 10.7270/Q2K35S8X | |||||||||||
More data for this Ligand-Target Pair |