BindingDB PrimarySearch

BDBM86748 CAS_386750-22-7::DESVENLAFAXINE::Desvenlafaxine::NSC_6918664::O-Desmethylvenlafaxine::US9944618, Compound ID No. 181

SMILES: CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1

InChI Key: InChIKey=KYYIDSXMWOZKMP-UHFFFAOYSA-N

Data: 31 KI 10 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 86748
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank US Patent	4.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q26D5WBR
Schering-Plough Research Institute					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									J Pharmacol Exp Ther 283: 1305-22 (1997) BindingDB Entry DOI: 10.7270/Q25Q4TMX
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									J Pharmacol Exp Ther 283: 1305-22 (1997) BindingDB Entry DOI: 10.7270/Q25Q4TMX
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	47.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank PubMed	115	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									J Pharmacol Exp Ther 283: 1305-22 (1997) BindingDB Entry DOI: 10.7270/Q25Q4TMX
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	531	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	558	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank US Patent	668	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q26D5WBR
Schering-Plough Research Institute					More data for this Ligand-Target Pair
Norepinephrine transporter (RAT)	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PubMed	938	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									J Pharmacol Exp Ther 283: 1305-22 (1997) BindingDB Entry DOI: 10.7270/Q25Q4TMX
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank PubMed	2.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									J Pharmacol Exp Ther 283: 1305-22 (1997) BindingDB Entry DOI: 10.7270/Q25Q4TMX
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank PubMed	3.15E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									J Pharmacol Exp Ther 283: 1305-22 (1997) BindingDB Entry DOI: 10.7270/Q25Q4TMX
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	3.39E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	US Patent	3.73E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q26D5WBR
Schering-Plough Research Institute					More data for this Ligand-Target Pair
SLC6A3 (GUINEA PIG)	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HRH1 (BOVINE)	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
HRH3 (RAT)	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adenosine transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
ADENOSINE A2 (BOVINE)	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adenosine receptor A1 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 318: 657-65 (2006) Article DOI: 10.1124/jpet.106.103382 BindingDB Entry DOI: 10.7270/Q2SF2TRS
Wyeth Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platform				J Pharmacol Toxicol Methods 70: 246-54 (2014) Article DOI: 10.1016/j.vascn.2014.07.002 BindingDB Entry DOI: 10.7270/Q2J104W7
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platform				J Pharmacol Toxicol Methods 70: 246-54 (2014) Article DOI: 10.1016/j.vascn.2014.07.002 BindingDB Entry DOI: 10.7270/Q2J104W7
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes				J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes				J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.51E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...				J Pharmacol Toxicol Methods 70: 246-54 (2014) Article DOI: 10.1016/j.vascn.2014.07.002 BindingDB Entry DOI: 10.7270/Q2J104W7
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...				J Pharmacol Toxicol Methods 70: 246-54 (2014) Article DOI: 10.1016/j.vascn.2014.07.002 BindingDB Entry DOI: 10.7270/Q2J104W7
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel subunit Kv4.3 (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.01E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...				J Pharmacol Toxicol Methods 70: 246-54 (2014) Article DOI: 10.1016/j.vascn.2014.07.002 BindingDB Entry DOI: 10.7270/Q2J104W7
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	n/a	n/a	538	n/a	n/a	n/a	n/a	n/a	n/a
Biocon Bristol-Myers Squibb R&D Centre Curated by ChEMBL					Assay Description Inhibition of human NET expressed in CHO cells assessed as reduction of [3H]-NE re-uptake preincubated for 10 mins followed by [3H]-NE addition measu...				J Med Chem 61: 2133-2165 (2018) Article DOI: 10.1021/acs.jmedchem.6b01827 BindingDB Entry DOI: 10.7270/Q2BV7K8M
Biocon Bristol-Myers Squibb R&D Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Biocon Bristol-Myers Squibb R&D Centre Curated by ChEMBL					Assay Description Inhibition of human SERT expressed in CHO cells assessed as reduction of [3H]-5-HT re-uptake preincubated for 10 mins followed by [3H]-5-HT addition ...				J Med Chem 61: 2133-2165 (2018) Article DOI: 10.1021/acs.jmedchem.6b01827 BindingDB Entry DOI: 10.7270/Q2BV7K8M
Biocon Bristol-Myers Squibb R&D Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM86748 (CAS_386750-22-7 \| DESVENLAFAXINE \| Desvenlafaxine ...) Show SMILES CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain				J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair