BDBM87158 N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-triazaspiro[4.5]decan-8-yl]-1-methyl-ethyl]-5-fluoro-1H-indole-2-carboxamide;2,2,2-trifluoroacetic acid::N-[(2S)-1-[1-(3,4-difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]-5-fluoro-1H-indole-2-carboxamide;2,2,2-trifluoroacetic acid::N-[(2S)-1-[1-[3,4-bis(fluoranyl)phenyl]-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]-5-fluoranyl-1H-indole-2-carboxamide;2,2,2-tris(fluoranyl)ethanoic acid::VU0404359-1::cid_53469960

SMILES: C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cc2cc(F)ccc2[nH]1

InChI Key: InChIKey=HWHBSTPKWDIKIG-HNNXBMFYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 87158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phospholipase D (PLD) (Homo sapiens (Human))	BDBM87158 (N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cc2cc(F)ccc2[nH]1 Show InChI InChI=1S/C25H26F3N5O2/c1-15(30-23(34)22-11-16-10-17(26)2-5-21(16)31-22)13-32-8-6-25(7-9-32)24(35)29-14-33(25)18-3-4-19(27)20(28)12-18/h2-5,10-12,15,31H,6-9,13-14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay					Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2NK3CNK
					More data for this Ligand-Target Pair
Phospholipase D2 (PLD2) (Homo sapiens (Human))	BDBM87158 (N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...) Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cc2cc(F)ccc2[nH]1 Show InChI InChI=1S/C25H26F3N5O2/c1-15(30-23(34)22-11-16-10-17(26)2-5-21(16)31-22)13-32-8-6-25(7-9-32)24(35)29-14-33(25)18-3-4-19(27)20(28)12-18/h2-5,10-12,15,31H,6-9,13-14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay					Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q21R6P4V
					More data for this Ligand-Target Pair