BDBM8750 4-(4-methoxyphenyl)-1-{[4-(trifluoromethyl)phenyl]methyl}-1H-imidazole::Disubstituted imidazole 29
SMILES: COc1ccc(cc1)-c1cn(Cc2ccc(cc2)C(F)(F)F)cn1
InChI Key: InChIKey=MOLDPFWVNBGONI-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Enoyl-ACP Reductase (FabI) (Escherichia coli) | BDBM8750 (4-(4-methoxyphenyl)-1-{[4-(trifluoromethyl)phenyl]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.83E+4 | n/a | n/a | n/a | n/a | n/a | 30 |
GlaxoSmithKline | Assay Description Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e... | Bioorg Med Chem Lett 11: 2061-5 (2001) Article DOI: 10.1016/s0960-894x(01)00404-8 BindingDB Entry DOI: 10.7270/Q28P5XQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Enoyl-ACP Reductase (FabI) (Staphylococcus aureus) | BDBM8750 (4-(4-methoxyphenyl)-1-{[4-(trifluoromethyl)phenyl]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.07E+3 | n/a | n/a | n/a | n/a | 6.5 | 30 |
GlaxoSmithKline | Assay Description Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e... | Bioorg Med Chem Lett 11: 2061-5 (2001) Article DOI: 10.1016/s0960-894x(01)00404-8 BindingDB Entry DOI: 10.7270/Q28P5XQG | |||||||||||
More data for this Ligand-Target Pair |