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SMILES: c1cn(cn1)-c1ccc2ccccc2c1

InChI Key: InChIKey=LHAAPZJTEBPKBJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8916   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM8916 (1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...) Show SMILES c1cn(cn1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10N2/c1-2-4-12-9-13(6-5-11(12)3-1)15-8-7-14-10-15/h1-10H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	7.4	37
Saarland University					Assay Description The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...				J Med Chem 48: 6632-42 (2005) Article DOI: 10.1021/jm0503704 BindingDB Entry DOI: 10.7270/Q2H41PNT
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM8916 (1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...) Show SMILES c1cn(cn1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10N2/c1-2-4-12-9-13(6-5-11(12)3-1)15-8-7-14-10-15/h1-10H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University					Assay Description The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...				J Med Chem 48: 6632-42 (2005) Article DOI: 10.1021/jm0503704 BindingDB Entry DOI: 10.7270/Q2H41PNT
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM8916 (1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...) Show SMILES c1cn(cn1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10N2/c1-2-4-12-9-13(6-5-11(12)3-1)15-8-7-14-10-15/h1-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University					Assay Description The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...				J Med Chem 48: 6632-42 (2005) Article DOI: 10.1021/jm0503704 BindingDB Entry DOI: 10.7270/Q2H41PNT
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM8916 (1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...) Show SMILES c1cn(cn1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10N2/c1-2-4-12-9-13(6-5-11(12)3-1)15-8-7-14-10-15/h1-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of aromatase				J Med Chem 51: 2481-91 (2008) Article DOI: 10.1021/jm701314u BindingDB Entry DOI: 10.7270/Q2GX4CF5
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM8916 (1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...) Show SMILES c1cn(cn1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10N2/c1-2-4-12-9-13(6-5-11(12)3-1)15-8-7-14-10-15/h1-10H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	37
UNIVERSITAT DES SAARLANDES US Patent					Assay Description V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...				US Patent US9271963 (2016) BindingDB Entry DOI: 10.7270/Q2445KBN
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM8916 (1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...) Show SMILES c1cn(cn1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10N2/c1-2-4-12-9-13(6-5-11(12)3-1)15-8-7-14-10-15/h1-10H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	7.4	n/a
UNIVERSITAT DES SAARLANDES US Patent					Assay Description The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...				US Patent US9271963 (2016) BindingDB Entry DOI: 10.7270/Q2445KBN
					More data for this Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM8916 (1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...) Show SMILES c1cn(cn1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10N2/c1-2-4-12-9-13(6-5-11(12)3-1)15-8-7-14-10-15/h1-10H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	37
UNIVERSITAT DES SAARLANDES US Patent					Assay Description V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...				US Patent US9271963 (2016) BindingDB Entry DOI: 10.7270/Q2445KBN
					More data for this Ligand-Target Pair