BDBM92353 Sorafenib derivative, 16

SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(c(Cl)cc3OCCCC(O)=O)C(F)(F)F)cc2)ccn1

InChI Key: InChIKey=PNEOMQHMTTZCGK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 92353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen Synthase Kinase 3 (GSK3) (Ustilago maydis (Smut fungus))	BDBM92353 (Sorafenib derivative, 16) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(c(Cl)cc3OCCCC(O)=O)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C25H22ClF3N4O6/c1-30-23(36)20-11-16(8-9-31-20)39-15-6-4-14(5-7-15)32-24(37)33-19-12-17(25(27,28)29)18(26)13-21(19)38-10-2-3-22(34)35/h4-9,11-13H,2-3,10H2,1H3,(H,30,36)(H,34,35)(H2,32,33,37)	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universität Dortmund					Assay Description Inhibition of UmGSK3 by kinase inhibitors.				ACS Chem Biol 7: 1257-67 (2012) Article DOI: 10.1021/cb300128b BindingDB Entry DOI: 10.7270/Q29S1PNH
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM92353 (Sorafenib derivative, 16) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(c(Cl)cc3OCCCC(O)=O)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C25H22ClF3N4O6/c1-30-23(36)20-11-16(8-9-31-20)39-15-6-4-14(5-7-15)32-24(37)33-19-12-17(25(27,28)29)18(26)13-21(19)38-10-2-3-22(34)35/h4-9,11-13H,2-3,10H2,1H3,(H,30,36)(H,34,35)(H2,32,33,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM92353 (Sorafenib derivative, 16) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(c(Cl)cc3OCCCC(O)=O)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C25H22ClF3N4O6/c1-30-23(36)20-11-16(8-9-31-20)39-15-6-4-14(5-7-15)32-24(37)33-19-12-17(25(27,28)29)18(26)13-21(19)38-10-2-3-22(34)35/h4-9,11-13H,2-3,10H2,1H3,(H,30,36)(H,34,35)(H2,32,33,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universität Dortmund					Assay Description Inhibition of UmGSK3 by kinase inhibitors.				ACS Chem Biol 7: 1257-67 (2012) Article DOI: 10.1021/cb300128b BindingDB Entry DOI: 10.7270/Q29S1PNH
					More data for this Ligand-Target Pair