BDBM92648 EPZ004450
SMILES: CN(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)CC1OC([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12
InChI Key: InChIKey=SXZVJXPNQRTMDB-YQORSWRPSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92648 (EPZ004450) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair |