BDBM92674 Isoquinolinesulfonamide, CKI-7

SMILES: NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12

InChI Key: InChIKey=OGKYMFFYOWUTKV-UHFFFAOYSA-N

Data: 7 IC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 92674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM92674 (Isoquinolinesulfonamide, CKI-7) Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM92674 (Isoquinolinesulfonamide, CKI-7) Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	9.00E+4	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM92674 (Isoquinolinesulfonamide, CKI-7) Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
					More data for this Ligand-Target Pair
Casein kinase I (Homo sapiens (Human))	BDBM92674 (Isoquinolinesulfonamide, CKI-7) Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CK1 (unknown origin)				Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111581
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase II (Bos taurus (Bovine))	BDBM92674 (Isoquinolinesulfonamide, CKI-7) Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.95E+5	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Homo sapiens (Human))	BDBM92674 (Isoquinolinesulfonamide, CKI-7) Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of CK1 using KRRRALS(p)VASLPGL as substrate after 40 mins by scintillation counter				Eur J Med Chem 56: 30-38 (2012) Article DOI: 10.1016/j.ejmech.2012.08.007 BindingDB Entry DOI: 10.7270/Q2FJ2J2F
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase type I-alpha regulatory subunit (Bos taurus)	BDBM92674 (Isoquinolinesulfonamide, CKI-7) Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.50E+5	n/a	n/a	n/a	n/a	7.4	30
Nagoya University School of Medicine					Assay Description Casein kinase activities were determined under the conditions as described by Huang et al (1982).				J Biol Chem 264: 4924-7 (1989) BindingDB Entry DOI: 10.7270/Q2K072VK
					More data for this Ligand-Target Pair