BDBM92867 4-Aminoquinazoline derivative, 6a

SMILES: Cc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)cc1Nc1ncc(cn1)-c1cccnc1

InChI Key: InChIKey=IIDXPMBKJWZQEU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 92867   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM92867 (4-Aminoquinazoline derivative, 6a) Show SMILES Cc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)cc1Nc1ncc(cn1)-c1cccnc1 Show InChI InChI=1S/C31H32N8O2/c1-22-5-6-25(16-28(22)38-31-33-19-24(20-34-31)23-4-2-9-32-18-23)37-30-27-8-7-26(17-29(27)35-21-36-30)41-13-3-10-39-11-14-40-15-12-39/h2,4-9,16-21H,3,10-15H2,1H3,(H,33,34,38)(H,35,36,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	191	n/a	n/a	n/a	n/a	n/a	n/a
Southeast University					Assay Description The kinase assay of Aurora A and B was measured using HTRF-kinEASE-STK discovery kit purchased from Cisbio.				Chem Biol Drug Des 81: 399-407 (2013) Article DOI: 10.1111/cbdd.12089 BindingDB Entry DOI: 10.7270/Q2Z31X71
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM92867 (4-Aminoquinazoline derivative, 6a) Show SMILES Cc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)cc1Nc1ncc(cn1)-c1cccnc1 Show InChI InChI=1S/C31H32N8O2/c1-22-5-6-25(16-28(22)38-31-33-19-24(20-34-31)23-4-2-9-32-18-23)37-30-27-8-7-26(17-29(27)35-21-36-30)41-13-3-10-39-11-14-40-15-12-39/h2,4-9,16-21H,3,10-15H2,1H3,(H,33,34,38)(H,35,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
Southeast University					Assay Description The kinase assay of Aurora A and B was measured using HTRF-kinEASE-STK discovery kit purchased from Cisbio.				Chem Biol Drug Des 81: 399-407 (2013) Article DOI: 10.1111/cbdd.12089 BindingDB Entry DOI: 10.7270/Q2Z31X71
					More data for this Ligand-Target Pair