BDBM92874 4-Aminoquinazoline derivative, 6i

SMILES: CCOC(=O)c1csc2cc(Nc3ncnc4cc(OCCCN(CC)CC)ccc34)ccc12

InChI Key: InChIKey=RHWPLTWVZOMUTO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 92874   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM92874 (4-Aminoquinazoline derivative, 6i) Show SMILES CCOC(=O)c1csc2cc(Nc3ncnc4cc(OCCCN(CC)CC)ccc34)ccc12 Show InChI InChI=1S/C26H30N4O3S/c1-4-30(5-2)12-7-13-33-19-9-11-21-23(15-19)27-17-28-25(21)29-18-8-10-20-22(26(31)32-6-3)16-34-24(20)14-18/h8-11,14-17H,4-7,12-13H2,1-3H3,(H,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	893	n/a	n/a	n/a	n/a	n/a	n/a
Southeast University					Assay Description The kinase assay of Aurora A and B was measured using HTRF-kinEASE-STK discovery kit purchased from Cisbio.				Chem Biol Drug Des 81: 399-407 (2013) Article DOI: 10.1111/cbdd.12089 BindingDB Entry DOI: 10.7270/Q2Z31X71
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM92874 (4-Aminoquinazoline derivative, 6i) Show SMILES CCOC(=O)c1csc2cc(Nc3ncnc4cc(OCCCN(CC)CC)ccc34)ccc12 Show InChI InChI=1S/C26H30N4O3S/c1-4-30(5-2)12-7-13-33-19-9-11-21-23(15-19)27-17-28-25(21)29-18-8-10-20-22(26(31)32-6-3)16-34-24(20)14-18/h8-11,14-17H,4-7,12-13H2,1-3H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	788	n/a	n/a	n/a	n/a	n/a	n/a
Southeast University					Assay Description The kinase assay of Aurora A and B was measured using HTRF-kinEASE-STK discovery kit purchased from Cisbio.				Chem Biol Drug Des 81: 399-407 (2013) Article DOI: 10.1111/cbdd.12089 BindingDB Entry DOI: 10.7270/Q2Z31X71
					More data for this Ligand-Target Pair