BDBM93183 Cathepsin Inhibitor, Column 6 Row 1
SMILES: CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
InChI Key: InChIKey=LWNYIRORDVHBPG-UQTORGHUSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cathepsin K (Homo sapiens (Human)) | BDBM93183 (Cathepsin Inhibitor, Column 6 Row 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | 5.5 | n/a |
SmithKline Beecham Pharmaceuticals | Assay Description Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ... | J Comb Chem 1: 207-15 (1999) Article DOI: 10.1021/cc9800374 BindingDB Entry DOI: 10.7270/Q2HQ3XHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin L (Homo sapiens (Human)) | BDBM93183 (Cathepsin Inhibitor, Column 6 Row 1) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 90 | n/a | n/a | n/a | n/a | n/a | n/a | 5.5 | n/a |
SmithKline Beecham Pharmaceuticals | Assay Description Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ... | J Comb Chem 1: 207-15 (1999) Article DOI: 10.1021/cc9800374 BindingDB Entry DOI: 10.7270/Q2HQ3XHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Homo sapiens (Human)) | BDBM93183 (Cathepsin Inhibitor, Column 6 Row 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 5.5 | n/a |
SmithKline Beecham Pharmaceuticals | Assay Description Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ... | J Comb Chem 1: 207-15 (1999) Article DOI: 10.1021/cc9800374 BindingDB Entry DOI: 10.7270/Q2HQ3XHJ | |||||||||||
More data for this Ligand-Target Pair |