BindingDB PrimarySearch

BDBM93207 Kinase inhibitor, 5

SMILES: Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(Nc3ccc(OCCN)cc3)ncc2c1

InChI Key: InChIKey=PVCFUSCWDDWVIQ-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 93207
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 10 (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Ephrin type-A receptor 3 (EPHA3) (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK7 (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 10 (Homo sapiens (Human))	BDBM93207 (Kinase inhibitor, 5) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<20	n/a	n/a	n/a	n/a	7.5	25
University of Washington					Assay Description Fluorescence assay used for determination of catch and release efficiency.				ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X
University of Washington					More data for this Ligand-Target Pair