BDBM93422 PHD Inhibitor, 12{1,1,2}
SMILES: CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
InChI Key: InChIKey=STTWGTPJKOYMRB-KYJUHHDHSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM93422 (PHD Inhibitor, 12{1,1,2}) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. | Assay Description PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI... | J Comb Chem 12: 676-86 (2010) Article DOI: 10.1021/cc100073a BindingDB Entry DOI: 10.7270/Q2B27SXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM93422 (PHD Inhibitor, 12{1,1,2}) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. | Assay Description PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI... | J Comb Chem 12: 676-86 (2010) Article DOI: 10.1021/cc100073a BindingDB Entry DOI: 10.7270/Q2B27SXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 2 (Homo sapiens (Human)) | BDBM93422 (PHD Inhibitor, 12{1,1,2}) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc. | Assay Description PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI... | J Comb Chem 12: 676-86 (2010) Article DOI: 10.1021/cc100073a BindingDB Entry DOI: 10.7270/Q2B27SXP | |||||||||||
More data for this Ligand-Target Pair |