BDBM97665 US8476295, 1.1.03

SMILES: OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1

InChI Key: InChIKey=HWGXVQXOZZVGKP-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 97665   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho kinase 2 (ROCKII) (Homo sapiens (Human))	BDBM97665 (US8476295, 1.1.03) Show SMILES OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1 |THB:18:16:12.13:10| Show InChI InChI=1S/C23H28N4O2/c28-8-9-29-22-3-1-2-16(10-22)15-27-20-5-6-21(27)13-19(12-20)25-18-4-7-23-17(11-18)14-24-26-23/h1-4,7,10-11,14,19-21,25,28H,5-6,8-9,12-13,15H2,(H,24,26)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	21	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1) (Homo Sapiens (Human))	BDBM97665 (US8476295, 1.1.03) Show SMILES OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1 |THB:18:16:12.13:10| Show InChI InChI=1S/C23H28N4O2/c28-8-9-29-22-3-1-2-16(10-22)15-27-20-5-6-21(27)13-19(12-20)25-18-4-7-23-17(11-18)14-24-26-23/h1-4,7,10-11,14,19-21,25,28H,5-6,8-9,12-13,15H2,(H,24,26)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	59	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Inspire US Patent					Assay Description Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).				US Patent US8476295 (2013) BindingDB Entry DOI: 10.7270/Q2H993TS
					More data for this Ligand-Target Pair