BDBM97678 US8476284, 9::US8497277, 10::US8497277, 9::US9133201, 9::US9181263, 6::US9278100, 6
SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C(=O)C=C
InChI Key: InChIKey=KALPRSFUZYGTNU-UHFFFAOYSA-N
Data: 8 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pharmacyclics, Inc. US Patent | Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. | US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pharmacyclics, Inc. US Patent | Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. | US Patent US8497277 (2013) BindingDB Entry DOI: 10.7270/Q2MW2FR5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pharmacyclics, Inc. US Patent | Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. | US Patent US8476284 (2013) BindingDB Entry DOI: 10.7270/Q2CJ8C3G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 60.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacyclics LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition... | US Patent US9278100 (2016) BindingDB Entry DOI: 10.7270/Q20C4TMX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
PHARMACYCLICS LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in... | US Patent US9181263 (2015) BindingDB Entry DOI: 10.7270/Q2765D5Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 60.9 | n/a | n/a | n/a | n/a | n/a | n/a |
PHARMACYCLICS LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in... | US Patent US9181263 (2015) BindingDB Entry DOI: 10.7270/Q2765D5Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacyclics LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition... | US Patent US9278100 (2016) BindingDB Entry DOI: 10.7270/Q20C4TMX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM97678 (US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | 7.4 | n/a |
PHARMACYCLICS, INC. US Patent | Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in... | US Patent US9133201 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02KC | |||||||||||
More data for this Ligand-Target Pair |