BDBM97710 US8476271, 16::US9145408, 362
SMILES: OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CC3CCCC(C3)C2)c1=O
InChI Key: InChIKey=COTYYZPYDJKKIS-KQMWNOITSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Opioid growth factor receptor-like protein 1 (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.40 | -10.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Purdue Pharma L.P.; Shionogi & Co., Ltd. US Patent | Assay Description ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto... | US Patent US9145408 (2015) BindingDB Entry DOI: 10.7270/Q2DJ5DD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.40 | -11.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Purdue Pharma, L.P.; Shionogi & Co., Ltd. US Patent | Assay Description In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. | US Patent US8476271 (2013) BindingDB Entry DOI: 10.7270/Q2416VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.63E+3 | -7.89 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Purdue Pharma, L.P.; Shionogi & Co., Ltd. US Patent | Assay Description In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. | US Patent US8476271 (2013) BindingDB Entry DOI: 10.7270/Q2416VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.63E+3 | -7.89 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Purdue Pharma L.P.; Shionogi & Co., Ltd. US Patent | Assay Description mu-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement binding assays for mu-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN,... | US Patent US9145408 (2015) BindingDB Entry DOI: 10.7270/Q2DJ5DD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.28E+3 | -7.69 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Purdue Pharma, L.P.; Shionogi & Co., Ltd. US Patent | Assay Description In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. | US Patent US8476271 (2013) BindingDB Entry DOI: 10.7270/Q2416VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.28E+3 | -7.15 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Purdue Pharma L.P.; Shionogi & Co., Ltd. US Patent | Assay Description Alpha-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned i... | US Patent US9145408 (2015) BindingDB Entry DOI: 10.7270/Q2DJ5DD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.76E+3 | -7.26 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Purdue Pharma L.P.; Shionogi & Co., Ltd. US Patent | Assay Description Beta-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 ug m... | US Patent US9145408 (2015) BindingDB Entry DOI: 10.7270/Q2DJ5DD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.76E+3 | -7.26 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Purdue Pharma, L.P.; Shionogi & Co., Ltd. US Patent | Assay Description In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. | US Patent US8476271 (2013) BindingDB Entry DOI: 10.7270/Q2416VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | 7.4 | 25 |
Purdue Pharma L.P.; Shionogi & Co., Ltd. US Patent | Assay Description Alpha-Opioid Receptor Functional Assay Procedures: Functional [35S]GTPgammaS binding assays were conducted as follows. Kappa opioid receptor membrane... | US Patent US9145408 (2015) BindingDB Entry DOI: 10.7270/Q2DJ5DD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid growth factor receptor-like protein 1 (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 4.03 | n/a | n/a | 7.4 | 4 |
Purdue Pharma L.P.; Shionogi & Co., Ltd. US Patent | Assay Description ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (... | US Patent US9145408 (2015) BindingDB Entry DOI: 10.7270/Q2DJ5DD3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM97710 (US8476271, 16 | US9145408, 362) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | 7.4 | 25 |
Purdue Pharma L.P.; Shionogi & Co., Ltd. US Patent | Assay Description Mu-Opioid Receptor Functional Assay Procedures: [35S]GTP gamma S functional assays were conducted using freshly thawed mu-receptor membranes. Assay r... | US Patent US9145408 (2015) BindingDB Entry DOI: 10.7270/Q2DJ5DD3 | |||||||||||
More data for this Ligand-Target Pair |