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BDBM97730 US8481564, 6

SMILES: OCc1cc(NC(=O)c2nc(c[nH]2)C#N)c(cc1C1CNS(=O)(=O)NC1)C1=CCCCC1

InChI Key: InChIKey=ZRWFZYJQPSPUJF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 97730   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97730
PNG
(US8481564, 6)
Show SMILES OCc1cc(NC(=O)c2nc(c[nH]2)C#N)c(cc1C1CNS(=O)(=O)NC1)C1=CCCCC1 |t:29|
Show InChI InChI=1S/C21H24N6O4S/c22-8-16-11-23-20(26-16)21(29)27-19-6-14(12-28)17(15-9-24-32(30,31)25-10-15)7-18(19)13-4-2-1-3-5-13/h4,6-7,11,15,24-25,28H,1-3,5,9-10,12H2,(H,23,26)(H,27,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)

More data for this
Ligand-Target Pair