BDBM97735 US8481564, 12

SMILES: O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(NC1)=NC#N)c1nc(c[nH]1)C#N

InChI Key: InChIKey=XXDKACJJRBNWRE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 97735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 (CSF-1) (Mus musculus (Mouse))	BDBM97735 (US8481564, 12) Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(NC1)=NC#N)c1nc(c[nH]1)C#N |t:10,(6.88,1.32,;5.55,.55,;4.22,1.32,;2.88,.55,;2.88,-.99,;1.55,-1.76,;.22,-.99,;.22,.55,;1.55,1.32,;1.55,2.86,;2.88,3.63,;2.88,5.17,;1.55,5.94,;.22,5.17,;.22,3.63,;-1.12,-1.76,;-1.12,-3.3,;-2.45,-4.07,;-3.78,-3.3,;-3.78,-1.76,;-2.45,-.99,;-5.12,-4.07,;-6.45,-3.3,;-7.79,-2.53,;6.32,-.78,;5.42,-2.03,;6.32,-3.27,;7.79,-2.8,;7.79,-1.26,;5.55,-4.61,;4.78,-5.94,)| Show InChI InChI=1S/C22H22N8O/c23-9-17-12-25-20(29-17)21(31)30-19-7-6-15(8-18(19)14-4-2-1-3-5-14)16-10-26-22(27-11-16)28-13-24/h4,6-8,12,16H,1-3,5,10-11H2,(H,25,29)(H,30,31)(H2,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica, N.V. US Patent					Assay Description A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...				US Patent US8481564 (2013) BindingDB Entry DOI: 10.7270/Q2QV3K4Q
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