null

SMILES: CS(=O)(=O)N=C1NCC(CN1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1

InChI Key: InChIKey=GJWGJJJKTOPKNH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 97736   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 (Mus musculus (Mouse))	BDBM97736 (US8481564, 13) Show SMILES CS(=O)(=O)N=C1NCC(CN1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:30,(-7.73,-4.07,;-6.4,-3.3,;-6.4,-1.76,;-6.4,-4.84,;-5.07,-4.07,;-3.73,-3.3,;-2.4,-4.07,;-1.07,-3.3,;-1.07,-1.76,;-2.4,-.99,;-3.73,-1.76,;.27,-.99,;1.6,-1.76,;2.94,-.99,;2.94,.55,;4.27,1.32,;5.6,.55,;6.94,1.32,;6.37,-.78,;5.47,-2.03,;6.37,-3.27,;7.84,-2.8,;7.84,-1.26,;5.6,-4.61,;4.83,-5.94,;1.6,1.32,;.27,.55,;1.6,2.86,;2.94,3.63,;2.94,5.17,;1.6,5.94,;.27,5.17,;.27,3.63,)| Show InChI InChI=1S/C22H25N7O3S/c1-33(31,32)29-22-25-11-16(12-26-22)15-7-8-19(18(9-15)14-5-3-2-4-6-14)28-21(30)20-24-13-17(10-23)27-20/h5,7-9,13,16H,2-4,6,11-12H2,1H3,(H,24,27)(H,28,30)(H2,25,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica, N.V. US Patent					Assay Description A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...				US Patent US8481564 (2013) BindingDB Entry DOI: 10.7270/Q2QV3K4Q
					More data for this Ligand-Target Pair