null
SMILES: CNC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
InChI Key: InChIKey=QCGBFIXSUJVWJN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM98028 (US10472367, Compound Formula II | US10919901, Comp...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Incyte Corporation US Patent | Assay Description The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity. | US Patent US8487096 (2013) BindingDB Entry DOI: 10.7270/Q2319THZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM98028 (US10472367, Compound Formula II | US10919901, Comp...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-Met... | US Patent US10919901 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM98028 (US10472367, Compound Formula II | US10919901, Comp...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION US Patent | Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d... | US Patent US10472367 (2019) BindingDB Entry DOI: 10.7270/Q2639S3S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM98028 (US10472367, Compound Formula II | US10919901, Comp...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M... | US Patent US9221824 (2015) BindingDB Entry DOI: 10.7270/Q2MP524M | |||||||||||
More data for this Ligand-Target Pair |