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SMILES: CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1

InChI Key: InChIKey=HMTSAUUBFGGHFU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 98030   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98030 (US10472367, Compound Formula IV | US10919901, Comp...) Show SMILES CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 Show InChI InChI=1S/C22H17N7O/c1-23-21(30)19-7-5-16(11-25-19)20-13-27-22-26-12-17(29(22)28-20)10-14-4-6-18-15(9-14)3-2-8-24-18/h2-9,11-13H,10H2,1H3,(H,23,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.5	30
Incyte Corporation US Patent					Assay Description The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity.				US Patent US8487096 (2013) BindingDB Entry DOI: 10.7270/Q2319THZ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98030 (US10472367, Compound Formula IV | US10919901, Comp...) Show SMILES CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 Show InChI InChI=1S/C22H17N7O/c1-23-21(30)19-7-5-16(11-25-19)20-13-27-22-26-12-17(29(22)28-20)10-14-4-6-18-15(9-14)3-2-8-24-18/h2-9,11-13H,10H2,1H3,(H,23,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-Met...				US Patent US10919901 (2021)
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98030 (US10472367, Compound Formula IV | US10919901, Comp...) Show SMILES CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 Show InChI InChI=1S/C22H17N7O/c1-23-21(30)19-7-5-16(11-25-19)20-13-27-22-26-12-17(29(22)28-20)10-14-4-6-18-15(9-14)3-2-8-24-18/h2-9,11-13H,10H2,1H3,(H,23,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION US Patent					Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...				US Patent US10472367 (2019) BindingDB Entry DOI: 10.7270/Q2639S3S
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98030 (US10472367, Compound Formula IV | US10919901, Comp...) Show SMILES CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 Show InChI InChI=1S/C22H17N7O/c1-23-21(30)19-7-5-16(11-25-19)20-13-27-22-26-12-17(29(22)28-20)10-14-4-6-18-15(9-14)3-2-8-24-18/h2-9,11-13H,10H2,1H3,(H,23,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.5	30
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M...				US Patent US9221824 (2015) BindingDB Entry DOI: 10.7270/Q2MP524M
					More data for this Ligand-Target Pair