BDBM9849 (2S)-6-{[(tert-butoxy)carbonyl]amino}-2-[(4-methylbenzene)sulfonamido]hexanoic acid::Lysine derivative 2
SMILES: Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(O)=O
InChI Key: InChIKey=GJXKBGKAUIMAKK-HNNXBMFYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM9849 ((2S)-6-{[(tert-butoxy)carbonyl]amino}-2-[(4-methyl...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | >-5.54 | n/a | n/a | n/a | n/a | n/a | 4.7 | 30 |
Pharmacor Inc | Assay Description HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-Ser-Gln-Asn-Tyr-Pr... | Bioorg Med Chem Lett 15: 1509-13 (2005) Article DOI: 10.1016/j.bmcl.2004.12.068 BindingDB Entry DOI: 10.7270/Q2Z31WW4 | |||||||||||
More data for this Ligand-Target Pair |