BDBM98737 US8487093, 82
SMILES: CN1CCC(CC1)NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O
InChI Key: InChIKey=CHULEIUYGBCUPR-MNOVXSKESA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-lactamase (KPC-2) (Klebsiella pneumoniae) | BDBM98737 (US8487093, 82) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. | US Patent US8487093 (2013) BindingDB Entry DOI: 10.7270/Q2057DKK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (Acinetobacter baumannii) | BDBM98737 (US8487093, 82) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Labs Curated by ChEMBL | Assay Description Inhibition of beta-lactamase Oxa40 in Acinetobacter baumannii assessed as inhibition of hydrolysis of nitrocefin | Bioorg Med Chem Lett 24: 780-5 (2014) Article DOI: 10.1016/j.bmcl.2013.12.101 BindingDB Entry DOI: 10.7270/Q2HD7X41 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase (AmpC) (Pseudomonas aeruginosa) | BDBM98737 (US8487093, 82) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay. | US Patent US8487093 (2013) BindingDB Entry DOI: 10.7270/Q2057DKK | |||||||||||
More data for this Ligand-Target Pair |