BDBM99564 US8501936, 62

SMILES: CN(c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)S(C)(=O)=O

InChI Key: InChIKey=HPJYKOYKZDLYMY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99564   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM99564 (US8501936, 62) Show SMILES CN(c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)S(C)(=O)=O Show InChI InChI=1S/C25H29N7O2S/c1-29-15-17-31(18-16-29)22-12-8-20(9-13-22)26-25-27-24-23(5-4-14-32(24)28-25)19-6-10-21(11-7-19)30(2)35(3,33)34/h4-14H,15-18H2,1-3H3,(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	999	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM99564 (US8501936, 62) Show SMILES CN(c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)S(C)(=O)=O Show InChI InChI=1S/C25H29N7O2S/c1-29-15-17-31(18-16-29)22-12-8-20(9-13-22)26-25-27-24-23(5-4-14-32(24)28-25)19-6-10-21(11-7-19)30(2)35(3,33)34/h4-14H,15-18H2,1-3H3,(H,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.9	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99564 (US8501936, 62) Show SMILES CN(c1ccc(cc1)-c1cccn2nc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)S(C)(=O)=O Show InChI InChI=1S/C25H29N7O2S/c1-29-15-17-31(18-16-29)22-12-8-20(9-13-22)26-25-27-24-23(5-4-14-32(24)28-25)19-6-10-21(11-7-19)30(2)35(3,33)34/h4-14H,15-18H2,1-3H3,(H,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair