BDBM99690 US8501936, 191

SMILES: CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)[C@@H]3CCN(CC(N)=O)C[C@@H]3O)nc12

InChI Key: InChIKey=CGPMWUPWDLVLFB-GMAHTHKFSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM99690 (US8501936, 191) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)[C@@H]3CCN(CC(N)=O)C[C@@H]3O)nc12 |r| Show InChI InChI=1S/C26H28N6O4S/c1-37(35,36)20-9-7-17(8-10-20)22-6-3-12-32-25(22)29-26(30-32)28-19-5-2-4-18(14-19)21-11-13-31(15-23(21)33)16-24(27)34/h2-10,12,14,21,23,33H,11,13,15-16H2,1H3,(H2,27,34)(H,28,30)/t21-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	999	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM99690 (US8501936, 191) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)[C@@H]3CCN(CC(N)=O)C[C@@H]3O)nc12 |r| Show InChI InChI=1S/C26H28N6O4S/c1-37(35,36)20-9-7-17(8-10-20)22-6-3-12-32-25(22)29-26(30-32)28-19-5-2-4-18(14-19)21-11-13-31(15-23(21)33)16-24(27)34/h2-10,12,14,21,23,33H,11,13,15-16H2,1H3,(H2,27,34)(H,28,30)/t21-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.2	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99690 (US8501936, 191) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)[C@@H]3CCN(CC(N)=O)C[C@@H]3O)nc12 |r| Show InChI InChI=1S/C26H28N6O4S/c1-37(35,36)20-9-7-17(8-10-20)22-6-3-12-32-25(22)29-26(30-32)28-19-5-2-4-18(14-19)21-11-13-31(15-23(21)33)16-24(27)34/h2-10,12,14,21,23,33H,11,13,15-16H2,1H3,(H2,27,34)(H,28,30)/t21-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair