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| Wt: 1117.4 BDBM213240  |
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATP-dependent Clp protease ATP-binding subunit ClpC1 (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 17.5 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-145] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 12 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-493] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 19.2 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-145,F2A] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-145,E89Q] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 65 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-145,E89A] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 127 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-145,F2Y] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 780 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-145,F80Y] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 124 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent Clp protease ATP-binding subunit ClpC1 [1-145,F80A] (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | 7.5 | 25 |
Novartis Institute for Tropical Diseases | Assay Description Isothermal titration calorimetry experiments were performed using an iTC200 (GEHealthcare) at 25 °C, with 15-20 μM ClpC1 (in 20 mM Tris-HCl, pH ... | J Biol Chem 288: 30883-91 (2013) Article DOI: 10.1074/jbc.M113.493767 BindingDB Entry DOI: 10.7270/Q2XW4HN6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kJ/mole | -TΔS° kJ/mole | ΔH° kJ/mole | log K | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|
| Caseinolytic protein C1 (ClpC1 NTD) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -45.1 | -5.37 | -39.7 | 7.90 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -44.2 | -3.58 | -40.6 | 7.75 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1 NTD-D1) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -44 | -5.66 | -38.3 | 7.71 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1 NTD E89Q) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -41.2 | 3.28 | -44.5 | 7.22 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1 NTD E89A) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -39.5 | -3.58 | -36.0 | 6.93 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1 NTD F80Y) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -39.5 | -6.56 | -32.9 | 6.92 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1 NTD F2Y) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -34.9 | -8.65 | -26.2 | 6.11 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1 NTD F80A) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -32.5 | -7.16 | -25.3 | 5.69 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
| Caseinolytic protein C1 (ClpC1 NTD F2A) (Mycobacterium tuberculosis) | BDBM213240 (Cyclomarin A1 (CymA1)) | GoogleScholar PDB | PC cid PC sid | -30.8 | -1.49 | -29.4 | 5.40 | 7.5 | 25 | |
Novartis Institute for Tropical Diseases | J Biol Chem 288: 30883-91 (2013) | |||||||||
