Enzyme Monomer Search

Marvin 2D Structure

Wt: 587.6
BDBM103302

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 21 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Mus musculus (Mouse))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme US Patent					Assay Description Activated ERK2 activity was determined in the IMAP assay format.				US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61
Merck Sharp & Dohme US Patent					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 17A (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	193	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	304	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Serine/threonine-protein kinase haspin [465-798] (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	398	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	503	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	508	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	535	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Aurora kinase C (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	632	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	783	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Misshapen-like kinase 1 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	942	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 [1-363] (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Casein kinase II subunit alpha' (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
George Washington University					Assay Description The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	300	n/a	n/a	n/a	7.5	30
George Washington University					Assay Description For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	213	n/a	n/a	n/a	7.5	15
George Washington University					Assay Description For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	233	n/a	n/a	n/a	7.5	15
George Washington University					Assay Description For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair
Serine/threonine-protein kinase haspin [465-798] (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	297	n/a	n/a	n/a	7.5	15
George Washington University					Assay Description For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...				Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH
George Washington University					More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this search
Cell (A)	Syringe (B)	Cell Links	Syringe Links	ΔG° kJ/mole	-TΔS° kJ/mole	ΔH° kJ/mole	log K	pH	Temp °C
MAP kinase ERK2 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6)	DrugBank GoogleScholar KEGG PDB	PC cid PC sid	-38.0	90.0	-128	6.55	7.5	30
George Washington University	BDBM103302 (SCH772984 \| US8546404, 6)	DrugBank GoogleScholar KEGG PDB	PC cid PC sid	Nat Chem Biol 10: 853-860 (2014)
MAP kinase ERK1 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6)	GoogleScholar PDB	PC cid PC sid	-36.8	49.4	-86.2	6.66	7.5	15
George Washington University	BDBM103302 (SCH772984 \| US8546404, 6)	GoogleScholar PDB	PC cid PC sid	Nat Chem Biol 10: 853-860 (2014)
MAP kinase ERK2 (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6)	DrugBank GoogleScholar KEGG PDB	PC cid PC sid	-36.4	51.9	-88.3	6.60	7.5	15
George Washington University	BDBM103302 (SCH772984 \| US8546404, 6)	DrugBank GoogleScholar KEGG PDB	PC cid PC sid	Nat Chem Biol 10: 853-860 (2014)
Haspin (465-798) (Homo sapiens (Human))	BDBM103302 (SCH772984 \| US8546404, 6)	GoogleScholar PDB	PC cid PC sid	-36.2	37.5	-73.7	6.57	7.5	15
George Washington University	BDBM103302 (SCH772984 \| US8546404, 6)	GoogleScholar PDB	PC cid PC sid	Nat Chem Biol 10: 853-860 (2014)