Enzyme Monomer Search

Marvin 2D Structure

Wt: 227.2 BDBM76297 Purchase	Wt: 207.2 BDBM50372524 Purchase	Wt: 193.1 BDBM50155928 Purchase	Wt: 144.1 BDBM50276373	Wt: 146.1 BDBM50276374
Wt: 188.1 BDBM50276376	Wt: 128.1 BDBM50276380	Wt: 198.2 BDBM50276381	Wt: 170.1 BDBM50276372	Wt: 230.1 BDBM50276377
Wt: 126.1 BDBM50276378 Purchase	Wt: 162.1 BDBM50276379	Wt: 133.1 BDBM50505850 Purchase	Wt: 236.3 BDBM50505848 Purchase	Wt: 227.2 BDBM50597953

Displayed 1 to 15 (of 1254 total ) | Next | Last >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 33 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50505850 (Dapansutrile \| OLT-1177 \| OLT1177) Show SMILES CS(=O)(=O)CCC#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2021.128101 BindingDB Entry DOI: 10.7270/Q2W95F4V
TBA					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50505850 (Dapansutrile \| OLT-1177 \| OLT1177) Show SMILES CS(=O)(=O)CCC#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assessed as reduction in IL-1beta level preincubated for 30 mins follow...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111822 BindingDB Entry DOI: 10.7270/Q2SN0D7D
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50505850 (Dapansutrile \| OLT-1177 \| OLT1177) Show SMILES CS(=O)(=O)CCC#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISA				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113417 BindingDB Entry DOI: 10.7270/Q2ZW1QP9
TBA					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276373 (CHEMBL4125713) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276377 (CHEMBL4129636) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276378 (CHEMBL4126941) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Transitional endoplasmic reticulum ATPase (Homo sapiens (Human))	BDBM50155928 (3,4-Methylenedioxyb-Nitrostyrene \| CHEMBL596380) Show SMILES [O-][N+](=O)\C=C\c1ccc2OCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of p97 in human HeLa cells assessed as reduction in proteasomal turnover of p97-dependent reporter substrate UbG76V-GFP incubated for 120 ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.113148 BindingDB Entry DOI: 10.7270/Q2HT2T24
TBA					More data for this Ligand-Target Pair
Transitional endoplasmic reticulum ATPase (Homo sapiens (Human))	BDBM50155928 (3,4-Methylenedioxyb-Nitrostyrene \| CHEMBL596380) Show SMILES [O-][N+](=O)\C=C\c1ccc2OCOc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.113148 BindingDB Entry DOI: 10.7270/Q2HT2T24
TBA					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50155928 (3,4-Methylenedioxyb-Nitrostyrene \| CHEMBL596380) Show SMILES [O-][N+](=O)\C=C\c1ccc2OCOc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Manchester Curated by ChEMBL					Assay Description Inhibition of NLRP3 in LPS stimulated mouse BMDM cells after 15 mins followed by addition of ATP by ELISA analysis				J Med Chem 59: 1691-710 (2016) Article DOI: 10.1021/acs.jmedchem.5b01091 BindingDB Entry DOI: 10.7270/Q2416ZZM
The University of Manchester Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50155928 (3,4-Methylenedioxyb-Nitrostyrene \| CHEMBL596380) Show SMILES [O-][N+](=O)\C=C\c1ccc2OCOc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of NLRP3 inflammasome activation in LPS-primed mouse bone marrow derived macrophages preincubated for 15 mins followed by addition of ATP ...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111822 BindingDB Entry DOI: 10.7270/Q2SN0D7D
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50155928 (3,4-Methylenedioxyb-Nitrostyrene \| CHEMBL596380) Show SMILES [O-][N+](=O)\C=C\c1ccc2OCOc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114357 BindingDB Entry DOI: 10.7270/Q2B56PTR
TBA					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50155928 (3,4-Methylenedioxyb-Nitrostyrene \| CHEMBL596380) Show SMILES [O-][N+](=O)\C=C\c1ccc2OCOc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion prein...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01007 BindingDB Entry DOI: 10.7270/Q2PN99FB
TBA					More data for this Ligand-Target Pair
Transcription factor p65 (Homo sapiens (Human))	BDBM50372524 (BAY-11-7082 \| CHEMBL403183) Show SMILES Cc1ccc(cc1)S(=O)(=O)\C=C\C#N Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC				Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63
Columbia University Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276376 (CHEMBL4126909) Show SMILES CC(=O)OC[C@H]1OCC(=O)C(F)=C1 \|r,c:11\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276381 (CHEMBL4128029) Show SMILES CCCC(=O)OC[C@H]1OCC(=O)C=C1 \|r,c:12\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276381 (CHEMBL4128029) Show SMILES CCCC(=O)OC[C@H]1OCC(=O)C=C1 \|r,c:12\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276377 (CHEMBL4129636) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276376 (CHEMBL4126909) Show SMILES CC(=O)OC[C@H]1OCC(=O)C(F)=C1 \|r,c:11\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276372 (CHEMBL4128176) Show SMILES CC(=O)OC[C@H]1OCC(=O)C=C1 \|r,c:10\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM76297 (MLS002152970 \| N-(3-methoxyphenyl)benzamide \| SMR0...) Show SMILES COc1cccc(NC(=O)c2ccccc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	4.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2RN369N
					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276373 (CHEMBL4125713) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276372 (CHEMBL4128176) Show SMILES CC(=O)OC[C@H]1OCC(=O)C=C1 \|r,c:10\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276378 (CHEMBL4126941) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50505848 (CHEMBL4443648) Show SMILES CCn1c(nc2cc(C)ccc12)-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111822 BindingDB Entry DOI: 10.7270/Q2SN0D7D
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50372524 (BAY-11-7082 \| CHEMBL403183) Show SMILES Cc1ccc(cc1)S(=O)(=O)\C=C\C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of NLRP3 inflammasome activation in LPS-primed mouse NG5 cells assessed as reduction in IL-1beta level incubated for 15followed by additio...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111822 BindingDB Entry DOI: 10.7270/Q2SN0D7D
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM76297 (MLS002152970 \| N-(3-methoxyphenyl)benzamide \| SMR0...) Show SMILES COc1cccc(NC(=O)c2ccccc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2WD3Z10
					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276380 (CHEMBL4127699) Show SMILES OC[C@H]1OCC(=O)C=C1 \|r,c:7\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276380 (CHEMBL4127699) Show SMILES OC[C@H]1OCC(=O)C=C1 \|r,c:7\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50597953 (AS-114 \| CHEMBL211693) Show SMILES Oc1cccc(NC(=O)Cc2ccccc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114194 BindingDB Entry DOI: 10.7270/Q2NV9P9V
TBA					More data for this Ligand-Target Pair
Sortase family protein (Staphylococcus aureus)	BDBM50372524 (BAY-11-7082 \| CHEMBL403183) Show SMILES Cc1ccc(cc1)S(=O)(=O)\C=C\C#N Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.29E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128652 BindingDB Entry DOI: 10.7270/Q2736VZ0
TBA					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276374 (CHEMBL4126946) Show SMILES OC[C@H]1OCC(=O)C[C@@H]1O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+6	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Homo sapiens (Human))	BDBM50276374 (CHEMBL4126946) Show SMILES OC[C@H]1OCC(=O)C[C@@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+6	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50276379 (CHEBI:16715 \| CHEMBL1234723) Show SMILES OC[C@H]1OCC(=O)[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.90E+7	n/a	n/a	n/a	n/a	n/a	n/a
The Noguchi Institute Curated by ChEMBL					Assay Description Inhibition of nigericin-induced NLRP3 inflammasome activation in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-stimulate...				Bioorg Med Chem 26: 3763-3772 (2018) Article DOI: 10.1016/j.bmc.2017.11.041 BindingDB Entry DOI: 10.7270/Q25H7JSX
The Noguchi Institute Curated by ChEMBL					More data for this Ligand-Target Pair