KEGG   Mus musculus (house mouse): 56175
Entry
56175             CDS       T01002                                 
Symbol
Bace2, 1110059C24Rik, AEPLC, ALP56, ARP1, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Name
(RefSeq) beta-site APP-cleaving enzyme 2
  KO
K07747  beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    56175 (Bace2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    56175 (Bace2)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.45  memapsin 1
     56175 (Bace2)
Peptidases and inhibitors [BR:mmu01002]
 Aspartic peptidases
  Family A1: pepsin family
   56175 (Bace2)
SSDB
Motif
Pfam: Asp TAXi_C TAXi_N
Other DBs
NCBI-GeneID: 56175
NCBI-ProteinID: NP_062390
MGI: 1860440
Ensembl: ENSMUSG00000040605
UniProt: Q9JL18 A0A0R4J0I8
Position
16:97157928..97244136
AA seq 514 aa
MGALLRALLLPVLAQWLLSAVPALAPAPFTLPLQVARATNHRASAVPGLGTPELPRADGL
ALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
NT seq 1545 nt   +upstreamnt  +downstreamnt
atgggcgcgctgcttcgagcactcttgctcccggtgctggcgcagtggctcttgagtgcg
gtccccgcgctggcccccgcgcccttcacgctgcccctccaagtggcccgggccacgaac
cacagagcctcggctgttcccggactcgggacccccgagttgccccgggccgatggtctg
gccctcgcactggagcctgtcagggctactgccaacttcttggctatggtggacaacctt
cagggggactctggccgcggctactacctagagatgctgatcgggacccctccgcagaag
gtacagattcttgtggacactggaagcagtaacttcgctgtggcaggtgccccacactcc
tacatagacacctactttgactcagagagctccagcacataccactccaagggctttgat
gtcactgtgaagtacacacagggaagctggactggctttgttggtgaggaccttgtcacc
atcccaaaaggcttcaacagctctttcttggtcaatattgccactattttcgagtctgag
aatttctttttgcctggtattaaatggaatggaatccttggacttgcttatgctgctttg
gccaagccatcaagctctctggagacattttttgattccctggtggcccaagcaaagatt
ccagacattttctccatgcagatgtgcggggctggattgccagtagctggttctggtacc
aacggaggtagtcttgtcctgggtgggattgaaccaagtttgtataaaggagatatctgg
tataccccaattaaagaggaatggtactatcaaatagaaatcctgaagttggaaattgga
ggccagaacctcaacctggactgcagagagtataacgcagacaaggccattgtggacagt
ggcaccacgctcctgcgcctgccccagaaggtgtttgatgcagtggtggaagctgtggca
cgaacatctctgattccagagttttctgatggcttctggacaggggcccagctggcatgc
tggacaaattctgaaacgccatgggcatatttccctaagatttctatctacctgagagat
gagaatgccagtcgctccttccggatcaccattctcccacagctctacattcagcccatg
atgggagctggtttcaattatgaatgctaccgttttggtatctcctcttccacaaatgcg
ctggtgattggtgcgaccgtgatggaaggcttctacgtggtctttgacagagctcagagg
agggtgggctttgcagtgagtccctgtgcagagattgaaggtaccacagtgtctgaaatt
tctgggcccttttccacggaagacatagccagcaactgtgttccagcacaggctctgaat
gagcccatcttgtggattgtgtcctatgccctgatgagtgtgtgtggagccattctcctg
gttctgatcctcctcctgctgctcccgctgcactgccgtcatgccccccgagaccctgag
gtagttaacgatgagtcctcactagtcagacatcgctggaaatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (46)   
   RefSeq(nuc) (2)   
   GenBank (22)   
   EMBL (22)   
Protein domain (3)   
   Pfam (3)   
All databases (76)   

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