KEGG   Homo sapiens (human): 4322
Entry
4322              CDS       T01001                                 
Symbol
MMP13, CLG3, MANDP1, MDST, MMP-13
Name
(RefSeq) matrix metallopeptidase 13
  KO
K07994  matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04657  IL-17 signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
Disease
H00479  Metaphyseal dysplasias
H02187  Spondyloepimetaphyseal dysplasia
Drug target
Apratastat: D08859
Cipemastat: D03517
Prinomastat: D03797
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    4322 (MMP13)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    4322 (MMP13)
   04928 Parathyroid hormone synthesis, secretion and action
    4322 (MMP13)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    4322 (MMP13)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M10
   4322 (MMP13)
SSDB
Motif
Pfam: Peptidase_M10 Hemopexin PG_binding_1 Reprolysin_4 Reprolysin_3 Reprolysin_5 DUF4953
Other DBs
NCBI-GeneID: 4322
NCBI-ProteinID: NP_002418
OMIM: 600108
HGNC: 7159
Ensembl: ENSG00000137745
UniProt: P45452 Q53H33
Structure
Position
11:complement(102942995..102955732)
AA seq 471 aa
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
NT seq 1416 nt   +upstreamnt  +downstreamnt
atgcatccaggggtcctggctgccttcctcttcttgagctggactcattgtcgggccctg
ccccttcccagtggtggtgatgaagatgatttgtctgaggaagacctccagtttgcagag
cgctacctgagatcatactaccatcctacaaatctcgcgggaatcctgaaggagaatgca
gcaagctccatgactgagaggctccgagaaatgcagtctttcttcggcttagaggtgact
ggcaaacttgacgataacaccttagatgtcatgaaaaagccaagatgcggggttcctgat
gtgggtgaatacaatgttttccctcgaactcttaaatggtccaaaatgaatttaacctac
agaattgtgaattacacccctgatatgactcattctgaagtcgaaaaggcattcaaaaaa
gccttcaaagtttggtccgatgtaactcctctgaattttaccagacttcacgatggcatt
gctgacatcatgatctcttttggaattaaggagcatggcgacttctacccatttgatggg
ccctctggcctgctggctcatgcttttcctcctgggccaaattatggaggagatgcccat
tttgatgatgatgaaacctggacaagtagttccaaaggctacaacttgtttcttgttgct
gcgcatgagttcggccactccttaggtcttgaccactccaaggaccctggagcactcatg
tttcctatctacacctacaccggcaaaagccactttatgcttcctgatgacgatgtacaa
gggatccagtctctctatggtccaggagatgaagaccccaaccctaaacatccaaaaacg
ccagacaaatgtgacccttccttatcccttgatgccattaccagtctccgaggagaaaca
atgatctttaaagacagattcttctggcgcctgcatcctcagcaggttgatgcggagctg
tttttaacgaaatcattttggccagaacttcccaaccgtattgatgctgcatatgagcac
ccttctcatgacctcatcttcatcttcagaggtagaaaattttgggctcttaatggttat
gacattctggaaggttatcccaaaaaaatatctgaactgggtcttccaaaagaagttaag
aagataagtgcagctgttcactttgaggatacaggcaagactctcctgttctcaggaaac
caggtctggagatatgatgatactaaccatattatggataaagactatccgagactaata
gaagaagacttcccaggaattggtgataaagtagatgctgtctatgagaaaaatggttat
atctattttttcaacggacccatacagtttgaatacagcatctggagtaaccgtattgtt
cgcgtcatgccagcaaattccattttgtggtgttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
3D Structure (48)   
   PDB (48)   
Protein domain (7)   
   Pfam (7)   
All databases (115)   

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