KEGG   Homo sapiens (human): 7786
Entry
7786              CDS       T01001                                 
Symbol
MAP3K12, DLK, HP09298, MEKK12, MUK, ZPK, ZPKP1
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 12
  KO
K04423  mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01594  MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7786 (MAP3K12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7786 (MAP3K12)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     7786 (MAP3K12)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  MLK family
   7786 (MAP3K12)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Pkinase_fungal ABC1
Other DBs
NCBI-GeneID: 7786
NCBI-ProteinID: NP_006292
OMIM: 600447
HGNC: 6851
Ensembl: ENSG00000139625
UniProt: Q12852
Structure
Position
12:complement(53479669..53501539)
AA seq 859 aa
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
NT seq 2580 nt   +upstreamnt  +downstreamnt
atggcttgcctccatgagacccgaacaccctctccttcctttgggggctttgtgtctacc
ctaagtgaggcatccatgcgcaagctggacccagacacttctgactgcactcccgagaag
gacctgacgcctacccatgtcctgcagctacatgagcaggatgcagggggcccaggggga
gcagctgggtcacctgagagtcgggcatccagagttcgagctgacgaggtgcgactgcag
tgccagagtggcagtggcttccttgagggcctctttggctgcctgcgccctgtctggacc
atgattggcaaagcctactccactgagcacaagcagcagcaggaagacctttgggaggtc
ccctttgaggaaatcctggacctgcagtgggtgggctcaggggcccagggtgctgtcttc
ctggggcgcttccacggggaggaggtggctgtgaagaaggtgcgagacctcaaagaaacc
gacatcaagcacttgcgaaagctgaagcaccccaacatcatcactttcaagggtgtgtgc
acccaggctccctgctactgcatcctcatggagttctgcgcccagggccagctgtatgag
gtactgcgggctggccgccctgtcaccccctccttactggttgactggtccatgggcatc
gctggtggcatgaactacctgcacctgcacaagattatccacagggatctcaagtcaccc
aacatgctaatcacctacgacgatgtggtgaagatctcagattttggcacttccaaggag
ctgagtgacaagagcaccaagatgtcctttgcagggacagtagcctggatggcccctgag
gtgatccgcaatgaacctgtgtctgagaaggtcgacatctggtcctttggcgtggtgcta
tgggaactgctgactggtgagatcccctacaaagacgtagattcctcagccattatctgg
ggtgtgggaagcaacagtctccatctgcccgtgccctccagttgcccagatggtttcaag
atcctgcttcgccagtgctggaatagcaaaccacgaaatcgcccatcattccgacagatc
ctgctgcatctggacattgcctcagctgatgtactctccacaccccaggagacttacttt
aagtcccaggcagagtggcgggaagaagtaaaactgcactttgaaaagattaagtcagaa
gggacctgtctgcaccgcctagaagaggaactggtgatgaggaggagggaggagctcaga
cacgccctggacatcagggagcactatgaaaggaagctggagagagccaacaacctgtat
atggaacttaatgccctcatgttgcagctggaactcaaggagagggagctgctcaggcga
gagcaagctttagagcggaggtgcccaggcctgctgaagccacacccttcccggggcctc
ctgcatggaaacacaatggagaagcttatcaagaagaggaatgtgccacagaagctgtca
ccccatagcaaaaggccagatatcctcaagacggagtctttgctccctaaactagatgca
gccctgagtggggtggggcttcctgggtgtcctaagggccccccctcaccaggacggagt
cgccgtggcaagacccgtcaccgcaaggccagcgccaaggggagctgtggggacctgcct
gggcttcgtacagctgtgccaccccatgaacctggaggaccaggaagcccagggggccta
ggagggggaccctcagcctgggaggcctgccctcccgccctccgtgggcttcatcatgac
ctcctgctccgcaaaatgtcttcatcgtccccagacctgctgtcagcagcactagggtcc
cggggccggggggccacaggcggagctggggatcctggctcaccacctccggcccggggt
gacaccccaccaagtgagggctcagcccctggctccaccagcccagattcacctggggga
gccaaaggggaaccacctcctccagtagggcctggtgaaggtgtggggcttctgggaact
ggaagggaagggacctcaggccggggaggaagccgggctgggtcccagcacttgacccca
gctgcactgctgtacagggctgccgtcacccgaagtcagaaacgtggcatctcatcggaa
gaggaggaaggagaggtagacagtgaagtagagctgacatcaagccagaggtggcctcag
agcctgaacatgcgccagtcactatctaccttcagctcagagaatccatcagatggggag
gaaggcacagctagtgaaccttcccccagtggcacacctgaagttggcagcaccaacact
gatgagcggccagatgagcggtctgatgacatgtgctcccagggctcagaaatcccactg
gacccacctccttcagaggtcatccctggccctgaacccagctccctgcccattccacac
caggaacttctcagagagcggggccctcccaattctgaggactcagactgtgacagcact
gaattggacaactccaacagcgttgatgccttgcggcccccagcttccctccctccatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (29)   
   RefSeq(nuc) (15)   
   GenBank (7)   
   EMBL (7)   
3D Structure (10)   
   PDB (10)   
Protein domain (4)   
   Pfam (4)   
All databases (89)   

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