KEGG   Homo sapiens (human): 1777
Entry
1777              CDS       T01001                                 
Symbol
DNASE2, AIPCS, DNASE2A, DNL, DNL2
Name
(RefSeq) deoxyribonuclease 2, lysosomal
  KO
K01158  deoxyribonuclease II [EC:3.1.22.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04623  Cytosolic DNA-sensing pathway
Network
nt06520  CGAS-STING signaling
  Element
N01571  DNA degradation by extracellular/endolysosomal DNAse
Disease
H02608  Autoinflammatory-pancytopenia syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1777 (DNASE2)
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    1777 (DNASE2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.22  Endodeoxyribonucleases producing 3'-phosphomonoesters
    3.1.22.1  deoxyribonuclease II
     1777 (DNASE2)
SSDB
Motif
Pfam: DNase_II
Other DBs
NCBI-GeneID: 1777
NCBI-ProteinID: NP_001366
OMIM: 126350
HGNC: 2960
Ensembl: ENSG00000105612
UniProt: O00115
Position
19:complement(12875209..12881449)
AA seq 360 aa
MIPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGG
WRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLL
DHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPW
VYNYQLEGIFAQEFPDLENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYS
GWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCV
SPKGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYKI
NT seq 1083 nt   +upstreamnt  +downstreamnt
atgatcccgctgctgctggcagcgctgctgtgcgtccccgccggggccctgacctgctac
ggggactccgggcagcctgtagactggttcgtggtctacaagctgccagctcttagaggg
tccggggaggcggcgcagagagggctgcagtacaagtatctggacgagagctccggaggc
tggcgggacggcagggcactcatcaacagcccggagggggccgtgggccgaagcctgcag
ccgctgtaccggagcaacaccagccagctcgccttcctgctctacaatgaccaaccgcct
caacccagcaaggctcaggactcttccatgcgtgggcacacgaagggtgtcctgctcctt
gaccacgatgggggcttctggctggtccacagtgtacctaacttccctccaccggcctcc
tctgctgcatacagctggcctcatagcgcctgtacctacgggcagaccctgctctgtgtg
tcttttcccttcgctcagttctcgaagatgggcaagcagctgacctacacctacccctgg
gtctataactaccagctggaagggatctttgcccaggaattccccgacttggagaatgtg
gtcaagggccaccacgttagccaagaaccctggaacagcagcatcacactcacatcccag
gccggggctgttttccagagctttgccaagttcagcaaatttggagatgacctgtactcc
ggctggttggcagcagcccttggtaccaacctgcaggtccagttctggcacaaaactgta
ggcatcctgccctctaactgctcggatatctggcaggttctgaatgtgaaccagatagct
ttccctggaccagccggcccaagcttcaacagcacagaggaccactccaaatggtgcgtg
tccccaaaagggccctggacctgcgtgggtgacatgaatcggaaccagggagaggagcaa
cggggtgggggcacactgtgtgcccagctgccagccctctggaaagccttccagccgctg
gtgaagaactaccagccctgtaatggcatggccaggaagcccagcagagcttataagatc
taa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
Protein domain (1)   
   Pfam (1)   
All databases (55)   

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