KEGG   Homo sapiens (human): 1785
Entry
1785              CDS       T01001                                 
Symbol
DNM2, CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5
Name
(RefSeq) dynamin 2
  KO
K23484  dynamin 2 [EC:3.6.5.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04144  Endocytosis
hsa04666  Fc gamma R-mediated phagocytosis
hsa04721  Synaptic vesicle cycle
hsa04961  Endocrine and other factor-regulated calcium reabsorption
hsa05100  Bacterial invasion of epithelial cells
hsa05132  Salmonella infection
Disease
H00264  Charcot-Marie-Tooth disease
H00700  Centronuclear myopathy
H00865  Lethal congenital contractural syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    1785 (DNM2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    1785 (DNM2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    1785 (DNM2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    1785 (DNM2)
  09156 Nervous system
   04721 Synaptic vesicle cycle
    1785 (DNM2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    1785 (DNM2)
   05100 Bacterial invasion of epithelial cells
    1785 (DNM2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1785 (DNM2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.5  Acting on GTP to facilitate cellular and subcellular movement
    3.6.5.5  dynamin GTPase
     1785 (DNM2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Dynamin
    1785 (DNM2)
  Lipid raft mediated endocytosis
   Caveolin-mediated endocytosis
    1785 (DNM2)
   RhoA-dependent endocytosis
    1785 (DNM2)
SSDB
Motif
Pfam: Dynamin_M Dynamin_N GED PH MMR_HSR1
Other DBs
NCBI-GeneID: 1785
NCBI-ProteinID: NP_001005360
OMIM: 602378
HGNC: 2974
Ensembl: ENSG00000079805
UniProt: P50570
Structure
Position
19:10718079..10831903
AA seq 870 aa
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKL
QSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKL
KEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLID
IEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDL
RQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLV
DSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRD
DMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGR
PPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPP
GIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
NT seq 2613 nt   +upstreamnt  +downstreamnt
atgggcaaccgcgggatggaagagctgatcccgctggtcaacaaactgcaggacgccttc
agctccatcggccagagctgccacctggacctgccgcagatcgctgtagtgggcggccag
agcgccggcaagagctcggtgctggagaacttcgtgggccgggacttccttccccgcggt
tcaggaatcgtcacccggcggcctctcattctgcagctcatcttctcaaaaacagaacat
gccgagtttttgcactgcaagtccaaaaagtttacagactttgatgaagtccggcaggag
attgaagcagagaccgacagggtcacggggaccaacaaaggcatctccccagtgcccatc
aaccttcgagtctactcgccacacgtgttgaacttgaccctcatcgacctcccgggtatc
accaaggtgcctgtgggcgaccagcctccagacatcgagtaccagatcaaggacatgatc
ctgcagttcatcagccgggagagcagcctcattctggctgtcacgcccgccaacatggac
ctggccaactccgacgccctcaagctggccaaggaagtcgatccccaaggcctacggacc
atcggtgtcatcaccaagcttgacctgatggacgagggcaccgacgccagggacgtcttg
gagaacaagttgctcccgttgagaagaggctacattggcgtggtgaaccgcagccagaag
gatattgagggcaagaaggacatccgtgcagcactggcagctgagaggaagttcttcctc
tcccacccggcctaccggcacatggccgaccgcatgggcacgccacatctgcagaagacg
ctgaatcagcaactgaccaaccacatccgggagtcgctgccggccctacgtagcaaacta
cagagccagctgctgtccctggagaaggaggtggaggagtacaagaactttcggcccgac
gaccccacccgcaaaaccaaagccctgctgcagatggtccagcagtttggggtggatttt
gagaagaggatcgagggctcaggagatcaggtggacactctggagctctccgggggcgcc
cgaatcaatcgcatcttccacgagcggttcccatttgagctggtgaagatggagtttgac
gagaaggacttacgacgggagatcagctatgccattaagaacatccatggagtcaggacc
gggcttttcaccccggacttggcattcgaggccattgtgaaaaagcaggtcgtcaagctg
aaagagccctgtctgaaatgtgtcgacctggttatccaggagctaatcaatacagttagg
cagtgtaccagtaagctcagttcctacccccggttgcgagaggagacagagcgaatcgtc
accacttacatccgggaacgggaggggagaacgaaggaccagattcttctgctgatcgac
attgagcagtcctacatcaacacgaaccatgaggacttcatcgggtttgccaatgcccag
cagaggagcacgcagctgaacaagaagagagccatccccaatcagggggagatcctggtg
atccgcaggggctggctgaccatcaacaacatcagcctgatgaaaggcggctccaaggag
tactggtttgtgctgactgccgagtcactgtcctggtacaaggatgaggaggagaaagag
aagaagtacatgctgcctctggacaacctcaagatccgtgatgtggagaagggcttcatg
tccaacaagcacgtcttcgccatcttcaacacggagcagagaaacgtctacaaggacctg
cggcagatcgagctggcctgtgactcccaggaagacgtggacagctggaaggcctcgttc
ctccgagctggcgtctaccccgagaaggaccaggcagaaaacgaggatggggcccaggag
aacaccttctccatggacccccaactggagcggcaggtggagaccattcgcaacctggtg
gactcatacgtggccatcatcaacaagtccatccgcgacctcatgccaaagaccatcatg
cacctcatgatcaacaatacgaaggccttcatccaccacgagctgctggcctacctatac
tcctcggcagaccagagcagcctcatggaggagtcggctgaccaggcacagcggcgggac
gacatgctgcgcatgtaccatgccctcaaggaggcgctcaacatcatcggtgacatcagc
accagcactgtgtccacgcctgtacccccgcctgtcgatgacacctggctccagagcgcc
agcagccacagccccactccacagcgccgaccggtgtccagcatacacccccctggccgg
cccccagcagtgaggggccccactccagggccccccctgattcctgttcccgtgggggca
gcagcctccttctcggcgcccccaatcccatcccggcctggaccccagagcgtgtttgcc
aacagtgacctcttcccagccccgcctcagatcccatctcggccagttcggatcccccca
gggattcccccaggagtgcccagcagaagaccccctgctgcgcccagccggcccaccatt
atccgcccagccgagccatccctgctcgactag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (45)   
   RefSeq(nuc) (5)   
   GenBank (20)   
   EMBL (20)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (89)   

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