KEGG   Homo sapiens (human): 3373
Entry
3373              CDS       T01001                                 
Symbol
HYAL1, HYAL-1, LUCA1, MPS9, NAT6
Name
(RefSeq) hyaluronidase 1
  KO
K01197  hyaluronoglucosaminidase [EC:3.2.1.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00531  Glycosaminoglycan degradation
hsa01100  Metabolic pathways
hsa04142  Lysosome
Module
hsa_M00076  Dermatan sulfate degradation
hsa_M00077  Chondroitin sulfate degradation
Network
nt06012  Glycosaminoglycan degradation
  Element
N00610  Dermatan sulfate degradation
Disease
H00133  Mucopolysaccharidosis type IX
H00421  Mucopolysaccharidosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00531 Glycosaminoglycan degradation
    3373 (HYAL1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    3373 (HYAL1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02042 Bacterial toxins [BR:hsa02042]
    3373 (HYAL1)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3373 (HYAL1)
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    3373 (HYAL1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.35  hyaluronoglucosaminidase
     3373 (HYAL1)
Bacterial toxins [BR:hsa02042]
 Toxins that damage the extracellular matrix
  Hyaluronidases/Collagenases
   3373 (HYAL1)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Enzymes
   3373 (HYAL1)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Enzymes
  3373 (HYAL1)
SSDB
Motif
Pfam: Glyco_hydro_56
Other DBs
NCBI-GeneID: 3373
NCBI-ProteinID: NP_149349
OMIM: 607071
HGNC: 5320
Ensembl: ENSG00000114378
UniProt: Q12794 A0A024R2X3
Structure
Position
3:complement(50299893..50312381)
AA seq 435 aa
MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
YPGWQAPWCERKSMW
NT seq 1308 nt   +upstreamnt  +downstreamnt
atggcagcccacctgcttcccatctgcgccctcttcctgaccttactcgatatggcccaa
ggctttaggggccccttgctacccaaccggcccttcaccaccgtctggaatgcaaacacc
cagtggtgcctggagaggcacggtgtggacgtggatgtcagtgtcttcgatgtggtagcc
aacccagggcagaccttccgcggccctgacatgacaattttctatagctcccagctgggc
acctacccctactacacgcccactggggagcctgtgtttggtggtctgccccagaatgcc
agcctgattgcccacctggcccgcacattccaggacatcctggctgccatacctgctcct
gacttctcagggctggcagtcatcgactgggaggcatggcgcccacgctgggccttcaac
tgggacaccaaggacatttaccggcagcgctcacgggcactggtacaggcacagcaccct
gattggccagctcctcaggtggaggcagtagcccaggaccagttccagggagctgcacgg
gcctggatggcaggcaccctccagctggggcgggcactgcgtcctcgcggcctctggggc
ttctatggcttccctgactgctacaactatgactttctaagccccaactacaccggccag
tgcccatcaggcatccgtgcccaaaatgaccagctagggtggctgtggggccagagccgt
gccctctatcccagcatctacatgcccgcagtgctggagggcacagggaagtcacagatg
tatgtgcaacaccgtgtggccgaggcattccgtgtggctgtggctgctggtgaccccaat
ctgccggtgctgccctatgtccagatcttctatgacacgacaaaccactttctgcccctg
gatgagctggagcacagcctgggggagagtgcggcccagggggcagctggagtggtgctc
tgggtgagctgggaaaatacaagaaccaaggaatcatgtcaggccatcaaggagtatatg
gacactacactggggcccttcatcctgaacgtgaccagtggggcccttctctgcagtcaa
gccctgtgctccggccatggccgctgtgtccgccgcaccagccaccccaaagccctcctc
ctccttaaccctgccagtttctccatccagctcacgcctggtggtgggcccctgagcctg
cggggtgccctctcacttgaagatcaggcacagatggctgtggagttcaaatgtcgatgc
taccctggctggcaggcaccgtggtgtgagcggaagagcatgtggtga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (44)   
   RefSeq(nuc) (10)   
   GenBank (17)   
   EMBL (17)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   Pfam (1)   
All databases (94)   

Download RDF
DBGET integrated database retrieval system