KEGG   Homo sapiens (human): 10461
Entry
10461             CDS       T01001                                 
Symbol
MERTK, MER, RP38, Tyro12, c-Eyk, c-mer
Name
(RefSeq) MER proto-oncogene, tyrosine kinase
  KO
K05117  c-mer proto-oncogene tyrosine kinase [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
Network
nt06535  Efferocytosis
  Element
N01751  Macrophage EPO signaling
N01762  MERTK-mediated recognition and engulfment
N01775  Inactivation of CaMKII by inducing SERCA2
N01781  Activation of LXRs by oxysterols
Disease
H00527  Retinitis pigmentosa
Drug target
Zanzalintinib (DG03273): D12650 D12651
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    10461 (MERTK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    10461 (MERTK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     10461 (MERTK)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  AXL family
   10461 (MERTK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Ig_3 Ig_2 fn3 ig I-set V-set Ig_6 Pkinase_fungal DUF4833
Other DBs
NCBI-GeneID: 10461
NCBI-ProteinID: NP_006334
OMIM: 604705
HGNC: 7027
Ensembl: ENSG00000153208
UniProt: Q12866
Structure
Position
2:111898607..112029561
AA seq 999 aa
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
NT seq 3000 nt   +upstreamnt  +downstreamnt
atggggccggccccgctgccgctgctgctgggcctcttcctccccgcgctctggcgtaga
gctatcactgaggcaagggaagaagccaagccttacccgctattcccgggaccttttcca
gggagcctgcaaactgaccacacaccgctgttatcccttcctcacgccagtgggtaccag
cctgccttgatgttttcaccaacccagcctggaagaccacatacaggaaacgtagccatt
ccccaggtgacctctgtcgaatcaaagcccctaccgcctcttgccttcaaacacacagtt
ggacacataatactttctgaacataaaggtgtcaaatttaattgctcaatcagtgtacct
aatatataccaggacaccacaatttcttggtggaaagatgggaaggaattgcttggggca
catcatgcaattacacagttttatccagatgatgaagttacagcaataatcgcttccttc
agcataaccagtgtgcagcgttcagacaatgggtcgtatatctgtaagatgaaaataaac
aatgaagagatcgtgtctgatcccatctacatcgaagtacaaggacttcctcactttact
aagcagcctgagagcatgaatgtcaccagaaacacagccttcaacctcacctgtcaggct
gtgggcccgcctgagcccgtcaacattttctgggttcaaaacagtagccgtgttaacgaa
cagcctgaaaaatccccctccgtgctaactgttccaggcctgacggagatggcggtcttc
agttgtgaggcccacaatgacaaagggctgaccgtgtccaagggagtgcagatcaacatc
aaagcaattccctccccaccaactgaagtcagcatccgtaacagcactgcacacagcatt
ctgatctcctgggttcctggttttgatggatactccccgttcaggaattgcagcattcag
gtcaaggaagctgatccgctgagtaatggctcagtcatgatttttaacacctctgcctta
ccacatctgtaccaaatcaagcagctgcaagccctggctaattacagcattggtgtttcc
tgcatgaatgaaataggctggtctgcagtgagcccttggattctagccagcacgactgaa
ggagccccatcagtagcacctttaaatgtcactgtgtttctgaatgaatctagtgataat
gtggacatcagatggatgaagcctccgactaagcagcaggatggagaactggtgggctac
cggatatcccacgtgtggcagagtgcagggatttccaaagagctcttggaggaagttggc
cagaatggcagccgagctcggatctctgttcaagtccacaatgctacgtgcacagtgagg
attgcagccgtcaccagagggggagttgggcccttcagtgatccagtgaaaatatttatc
cctgcacacggttgggtagattatgccccctcttcaactccggcgcctggcaacgcagat
cctgtgctcatcatctttggctgcttttgtggatttattttgattgggttgattttatac
atctccttggccatcagaaaaagagtccaggagacaaagtttgggaatgcattcacagag
gaggattctgaattagtggtgaattatatagcaaagaaatccttctgtcggcgagccatt
gaacttaccttacatagcttgggagtcagtgaggaactacaaaataaactagaagatgtt
gtgattgacaggaatcttctaattcttggaaaaattctgggtgaaggagagtttgggtct
gtaatggaaggaaatcttaagcaggaagatgggacctctctgaaagtggcagtgaagacc
atgaagttggacaactcttcacagcgggagatcgaggagtttctcagtgaggcagcgtgc
atgaaagacttcagccacccaaatgtcattcgacttctaggtgtgtgtatagaaatgagc
tctcaaggcatcccaaagcccatggtaattttacccttcatgaaatacggggacctgcat
acttacttactttattcccgattggagacaggaccaaagcatattcctctgcagacacta
ttgaagttcatggtggatattgccctgggaatggagtatctgagcaacaggaattttctt
catcgagatttagctgctcgaaactgcatgttgcgagatgacatgactgtctgtgttgcg
gacttcggcctctctaagaagatttacagtggcgattattaccgccaaggccgcattgct
aagatgcctgttaaatggatcgccatagaaagtcttgcagaccgagtctacacaagtaaa
agtgatgtgtgggcatttggcgtgaccatgtgggaaatagctacgcggggaatgactccc
tatcctggggtccagaaccatgagatgtatgactatcttctccatggccacaggttgaag
cagcccgaagactgcctggatgaactgtatgaaataatgtactcttgctggagaaccgat
cccttagaccgccccaccttttcagtattgaggctgcagctagaaaaactcttagaaagt
ttgcctgacgttcggaaccaagcagacgttatttacgtcaatacacagttgctggagagc
tctgagggcctggcccagggctccacccttgctccactggacttgaacatcgaccctgac
tctataattgcctcctgcactccccgcgctgccatcagtgtggtcacagcagaagttcat
gacagcaaacctcatgaaggacggtacatcctgaatgggggcagtgaggaatgggaagat
ctgacttctgccccctctgctgcagtcacagctgaaaagaacagtgttttaccgggggag
agacttgttaggaatggggtctcctggtcccattcgagcatgctgcccttgggaagctca
ttgcccgatgaacttttgtttgctgacgactcctcagaaggctcagaagtcctgatgtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (5)   
   KEGG NETWORK (5)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (31)   
   RefSeq(nuc) (1)   
   GenBank (15)   
   EMBL (15)   
3D Structure (36)   
   PDB (36)   
Protein domain (11)   
   Pfam (11)   
All databases (114)   

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